Effects of vitamin E treatment on peroxisome proliferator-activated receptor-alpha expression and insulin resistance in patients with non-alcoholic steatohepatitis: results of a pilot study

Yakaryilmaz F., Guliter S., Savas B., ERDEM O. A., Ersoy R., Erden E., ...Daha Fazla

INTERNAL MEDICINE JOURNAL, cilt.37, sa.4, ss.229-235, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1111/j.1445-5994.2006.01295.x
  • Dergi Adı: INTERNAL MEDICINE JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.229-235
  • Anahtar Kelimeler: non-alcoholic steatohepatitis, insulin resistance, peroxisome proliferator-activated receptor-alpha, vitamin E, FATTY LIVER-DISEASE, PATHOGENESIS, DEFINITION, FIBROSIS, DIET
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Insulin resistance (IR) is commonly associated with non-alcoholic steatohepatitis (NASH). Peroxisome proliferator-activated receptor-alpha (PPAR-alpha) may also play a role in the pathogenesis of NASH. A pivotal role in NASH pathogenesis depends on the hypothesis of increased oxidative stress. The aim of our study was to evaluate the effects of supplemental oral vitamin E, a potent antioxidant, on liver functions, PPAR-alpha expression and IR in patients with NASH.