Effects of vitamin E treatment on peroxisome proliferator-activated receptor-alpha expression and insulin resistance in patients with non-alcoholic steatohepatitis: results of a pilot study

Yakaryilmaz F., Guliter S., Savas B., ERDEM O. A. , Ersoy R., Erden E., ...More

INTERNAL MEDICINE JOURNAL, vol.37, no.4, pp.229-235, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1111/j.1445-5994.2006.01295.x
  • Page Numbers: pp.229-235
  • Keywords: non-alcoholic steatohepatitis, insulin resistance, peroxisome proliferator-activated receptor-alpha, vitamin E, FATTY LIVER-DISEASE, PATHOGENESIS, DEFINITION, FIBROSIS, DIET


Background: Insulin resistance (IR) is commonly associated with non-alcoholic steatohepatitis (NASH). Peroxisome proliferator-activated receptor-alpha (PPAR-alpha) may also play a role in the pathogenesis of NASH. A pivotal role in NASH pathogenesis depends on the hypothesis of increased oxidative stress. The aim of our study was to evaluate the effects of supplemental oral vitamin E, a potent antioxidant, on liver functions, PPAR-alpha expression and IR in patients with NASH.