Candida vaginitis during contraceptive use: the influence of methods, antifungal susceptibility and virulence patterns.

Guzel A. B., Kucukgoz-Gulec U., Aydin M., Gumral R., Kalkanci A., Ilkit M.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, cilt.33, sa.8, ss.850-6, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 8
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/01443615.2013.834306
  • Dergi Adı: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.850-6
  • Anahtar Kelimeler: Candida albicans, Candida glabrata, contraceptive methods, fluconazole, intrauterine devices, vulvovaginitis, VULVO-VAGINAL CANDIDIASIS, RISK-FACTORS, BORIC-ACID, PRESUMPTIVE IDENTIFICATION, INTRAUTERINE-DEVICE, CHROMAGAR CANDIDA, ALBICANS, WOMEN, GLABRATA, EPIDEMIOLOGY
  • Gazi Üniversitesi Adresli: Evet

Özet

No consensus exists about whether contraceptives cause an increased risk of vaginitis, including vulvovaginal candidosis (VVC). We investigated 495 women (252 who used contraceptives; 243 who did not) for the presence of VVC. Antifungal susceptibility testing was performed for five antifungal agents and for boric acid, and three virulence factors were also examined. We recovered 129 (26.1%) monofungal populations from vaginal samples of women with acute VVC (AVVC, n = 18), symptomatic recurrent VVC (RVVC, n = 22) and asymptomatic RVVC (n = 28), as well as of other contraceptive users who carried Candida in their vaginas (n = 61). It is important to note that the women who had VVC used the same contraceptive methods (p > 0.05). Candida albicans was the most common species isolated (45%), followed by C. glabrata (40.3%). Most of the vaginal yeast isolates exhibited low minimum inhibitory concentration levels for the five antifungals tested. However, this was not the case for boric acid. In addition, the yeast fungi that was derived from the AVVC and RVVC patients showed higher amounts of haemolytic activity than the yeast fungi found among the controls (p < 0.05). The use of contraception does not predispose women to VVC (p > 0.05). Also, both host- and organism-related factors were required to achieve optimal clinical treatment for VVC.