Asimetrik Schiff Bazı Ni(II) Komplekslerinin Antimutajenik Aktivitesinin Değerlendirilmesi


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Nartop D., Hasanoğlu Özkan E. , Kızıl H. E. , Ağar G., Sarı N.

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, cilt.8, ss.608-616, 2020 (Hakemli Üniversite Dergisi)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8
  • Basım Tarihi: 2020
  • Doi Numarası: 10.29130/dubited.575747
  • Dergi Adı: Düzce Üniversitesi Bilim ve Teknoloji Dergisi
  • Sayfa Sayıları: ss.608-616

Özet

In this work, Ni(II) complexes with unsymmetric Schiff bases (NiL1, NiL2, NiL3, NiL4) were prepared by a two-stage method reported by one of us recently for investigate antimutagenic properties. Sodium azide-induced antimutagenic effect in lymphocytes was determined by sister chromatid exchange (SCE) and micronucleus (MN) methods. It has been determined that the synthesized compounds have antimutagenic properties and reduce the mutagenicity caused by sodium azide (NaN3) which is used as a positive control.