Synthesis, characterization and antibacterial activity of new sulfonyl hydrazone derivatives and their nickel(II) complexes

ÖZDEMİR ÖZMEN Ü., Olgun G.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, cilt.70, sa.3, ss.641-645, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Sayı: 3
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.saa.2007.08.012
  • Dergi Adı: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.641-645
  • Anahtar Kelimeler: aroylsulfonylhydrazone, Ni(II) complexes, sulfonamide derivatives, antibacterial activity, BIOLOGICAL-ACTIVITY, METAL-CARBONYLS, ANTIMICROBIAL ACTIVITY, SCHIFF-BASES, METHANESULFONYLHYDRAZONE, ETHANESULFONYLHYDRAZONE, RE(CO)(5)BR, MN(CO)(3)CP, ANALOGS, AGENTS
  • Gazi Üniversitesi Adresli: Evet

Özet

Prophane sulfonic acid hydrazide (psh: CH3CH2CH2SO2NHNH2) derivatives as salicylaldehydeprophanesulfonylhydrazone (salpsh), 5-methylsalicylaldehydeprophanesulfonylhydrazone (5-msalpsh), 2-hydroxyacetophenoneprophanesulfonylhydrazone (afpsh), 5-methyl-2-hydroxyacetophenoneprophanesulfonylhydrazone (5-mafpsh) and their Ni(II) complexes have been synthesized. The structure of these compounds has been investigated by using elemental analysis, FFIR, H-1 NMR, LC/MS, UV-vis spectrophotometric method, magnetic susceptibility and conductivity measurements. The complexes were found to have general compositions [NiL2]. Square-planer structures are proposed for the Ni(II) complexes on the basis of magnetic evidence, electronic spectra and TGA data. Bacterial activities of sulfonyl hydrazone compounds were studied against gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis, Bacillus magaterium and gram-negative bacteria: Salmonella enteritidis, Escherichia coli by using minimum inhibitory concentrations (MICs) method. (C) 2007 Elsevier B.V. All rights reserved.