Synthesis, characterization and antibacterial activity of new sulfonyl hydrazone derivatives and their nickel(II) complexes


ÖZDEMİR ÖZMEN Ü., Olgun G.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, vol.70, no.3, pp.641-645, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1016/j.saa.2007.08.012
  • Journal Name: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.641-645
  • Keywords: aroylsulfonylhydrazone, Ni(II) complexes, sulfonamide derivatives, antibacterial activity, BIOLOGICAL-ACTIVITY, METAL-CARBONYLS, ANTIMICROBIAL ACTIVITY, SCHIFF-BASES, METHANESULFONYLHYDRAZONE, ETHANESULFONYLHYDRAZONE, RE(CO)(5)BR, MN(CO)(3)CP, ANALOGS, AGENTS
  • Gazi University Affiliated: Yes

Abstract

Prophane sulfonic acid hydrazide (psh: CH3CH2CH2SO2NHNH2) derivatives as salicylaldehydeprophanesulfonylhydrazone (salpsh), 5-methylsalicylaldehydeprophanesulfonylhydrazone (5-msalpsh), 2-hydroxyacetophenoneprophanesulfonylhydrazone (afpsh), 5-methyl-2-hydroxyacetophenoneprophanesulfonylhydrazone (5-mafpsh) and their Ni(II) complexes have been synthesized. The structure of these compounds has been investigated by using elemental analysis, FFIR, H-1 NMR, LC/MS, UV-vis spectrophotometric method, magnetic susceptibility and conductivity measurements. The complexes were found to have general compositions [NiL2]. Square-planer structures are proposed for the Ni(II) complexes on the basis of magnetic evidence, electronic spectra and TGA data. Bacterial activities of sulfonyl hydrazone compounds were studied against gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis, Bacillus magaterium and gram-negative bacteria: Salmonella enteritidis, Escherichia coli by using minimum inhibitory concentrations (MICs) method. (C) 2007 Elsevier B.V. All rights reserved.