Tolmetin: An Option for Multiple NSAID Hypersensitivity in a Preschooler

Yilmaz O., Karagol I. H. E. , Topal E., Demirsoy M. S. , TÜRKTAŞ İ. , BAKIRTAŞ A.

PEDIATRIC ALLERGY IMMUNOLOGY AND PULMONOLOGY, cilt.26, sa.3, ss.164-165, 2013 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Konu: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1089/ped.2012.0185
  • Sayfa Sayıları: ss.164-165


The diagnostic process of multiple nonsteroidal anti-inflammatory drug (NSAID)-induced hypersensitivity should result with providing the patient a safe alternative. However, concomitant reactivity to acetaminophen severely limits those options in children, as no approved drug is available especially for children below the age of 12. A 3-year-old boy developed facial angioedema with ibuprofen, ketoprofen, metamizole sodium, and acetaminophen, but tolerated tolmetin sodium, which is confirmed by a challenge test. He has also used it as an antipyretic during febrile infections without any reaction. This is the first report suggesting an approved drug, tolmetin sodium, as a safe alternative for multiple NSAID-concomitant acetaminophen-reactive children.