In Vitro Genotoxic Effects of Four Helichrysum Species in Human Lymphocytes Cultures

Eroglu E. H., Hamzaoglu E., Aksoy A., Budak U., ÖZKUL Y.

BIOLOGICAL RESEARCH, cilt.43, sa.2, ss.177-182, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.4067/s0716-97602010000200005
  • Dergi Adı: BIOLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.177-182
  • Anahtar Kelimeler: genotoxic, Helichrysum, micronucleus, mitotic index, replication index, PROLIFERATION, MICRONUCLEI, FREQUENCY
  • Gazi Üniversitesi Adresli: Hayır

Özet

Helichrysum sanguineum, Helichrysum pamphylicum, Helichrysum orientate, Helichrysum noeanum (Asteraceae) are medicinal plants. For centuries, they have been used as tea in Turkey because of their medicinal properties. So far no scientific evidence has been found in a literature survey regarding the genotoxic effects of these plants. This work evaluated the genotoxic effects on human lymphocyte cultures induced by methanol extracts of these plants, assayed in different concentrations (0.01, 0.05, 0.1, 0.5 and 1 mg/mL). According to the results, Helichrysum noeanum, Helichrysum pamphylicum and Helichrysum sanguineum induced the formation of micronuclei and decreased the mitotic and replication indexes. Helichrysum orientate did not affect these parameters, whereas Helichrysum noeanum, Helichrysum pamphylicum and Helichrysum sanguineum were clearly genotoxic. They should therefore not be used freely in alternative medicine, although their antiproliferative activity may suggest antimitotic and anticarcinogenic properties. Helichrysum orientate could be used in alternative medicine.