Akademik Veri Yönetim Sistemi
European Federation for Pharmaceutical Sciences, Vienna, Avusturya, 19 - 21 Şubat 2025, (Özet Bildiri)
Cyclodextrin-MOFs have recently attracted attention as an alternative
drug delivery system with high porosity, surface area, micro-nano sized
particle size, and biocompatibility properties eliminating the toxicity risk of
metal ion and organic binder in the structures of conventional MOFs [1]. The aim of this study is to
prepare optimized nano sized CD-MOF using cetyl trimethyl ammonium bromide (CTA),
polyethylene glycol 20000 (PEG20000) and triethylamine (TEA) as particle size
modulators [2].
Gamma-cyclodextrin metal-organic framework was
prepared by modified methanol diffusion method [3]. CTAB, TEA and PEG20000 were used as particle size modulators. CD:
particle size modulator weight ratios were used at 0.5, 1.5, 3.5. Particle size, polydispersity index and zeta
potential were measured. When the results were examined, 1.5 was selected for
the formulation prepared with PEG20000. The lowest particle size was obtained
at this rate. The Pdı value and zeta potential show that a uniform and stable formulation
was obtained. In the formulation developed with CTAB, a ratio of 0.5 was
selected. This formulation has a better zeta potential than other formulations.
The PDI value was found to be the lowest. When TEA was used, the ratio of 3.5
was selected. This is because it was found to be more optimum than other
formulations when looking at the pdi value and particle size (Table 1).
TEA, CTAB and PEG20000 are particle size modulators
used in the literature to prepare CD-MOF. In this study, CD-MOFs were prepared
using these three particle size modulators with different molecular weights and
chemical properties. For further studies, optimum formulations were selected
according to the results obtained in terms of particle size, pdi and zeta
potential values.
Table 1. Optimization table of formulations
|
|
CD: Particle size modulator (weight ratio) |
Particle size (nm) ±SD |
Polydispersity index ±SD |
Zeta potential (mV)±SD |
|
PEG20000 |
0,5 |
367,5±19,22 |
0,196±0,053 |
-14,26±1,68 |
|
|
1,5 |
309,73±98,502 |
0,306±0,018 |
-13,86±2,27 |
|
|
3,5 |
327,066±16,536 |
0,301±0,064 |
-29±2,1 |
|
CTAB |
0,5 |
367,5±14,8 |
0,236±0,054 |
-14,933±1,91 |
|
|
1,5 |
504,23±75,407 |
0,567±0,092 |
-6,24±1,15 |
|
|
3,5 |
306,2±53,43 |
0,287±0,153 |
-6,02±1,7 |
|
TEA |
0,5 |
340,8±36,541 |
0,825±0,096 |
-16,66±2,205 |
|
|
1,5 |
786,26±58,48 |
0,475±0,127 |
-22,83±4,37 |
|
|
3,5 |
574,33±240,6 |
0,633±0,186 |
-12,93±1,66 |