Development and Full Validation of a Stability-indicating HPLC Method for the Determination of the Anticancer Drug Temozolomide in Pharmaceutical Form

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Kapcak E., Satana-Kara E. H.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.15, sa.3, ss.271-277, 2018 (ESCI, Scopus, TRDizin)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 15 Sayı: 3
• Basım Tarihi: 2018
• Doi Numarası: 10.4274/tjps.43265
• Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
• Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.271-277
• Anahtar Kelimeler: Temozolomide, HPLC, validation, determination, degradation, ANTITUMOR IMIDAZOTETRAZINES, DEGRADATION, RESISTANCE, BEHAVIOR, PRODUCT, PLASMA, AGENT, RAT, DNA
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Gazi Üniversitesi Adresli: Evet

Özet

Objectives: In the present study, an accurate, precise and simple method has been developed for the determination of TMZ in its pharmaceutical form by using HPLC.