Epiretinal human amniotic membrane grafting for macular hole with macular telangiectasia type 2
Retinal Cases and Brief Reports, 2026 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1097/icb.0000000000001930
- Dergi Adı: Retinal Cases and Brief Reports
- Derginin Tarandığı İndeksler: Scopus, EMBASE, MEDLINE
- Anahtar Kelimeler: Complex macular hole, epiretinal amniotic membrane, full-thickness macular hole, human amniotic membrane, MacTel, macular hole, macular telangiectasia type 2
- Gazi Üniversitesi Adresli: Evet
Özet
Purpose: – Macular telangiectasia (MacTel) type 2 is a progressive neurodegenerative condition with complications including macular hole. Conventional repair of an associated hole does not reliably improve vision despite an increasing number of described and advanced surgical techniques. The study objective was to determine whether epiretinal human amniotic membrane grafting can restore anatomy and vision in eyes complicated by macular hole with MacTel.Methods: – In this international, multicenter, interventional case series, three patients with macular hole and MacTel consented to surgical repair with pars plana vitrectomy and epiretinal human amniotic membrane grafting. One had at least two prior vitrectomies with initially successful full-thickness macular hole closure that reopened, years in between surgeries, prior to graft surgery. One had a persistent full-thickness macular hole refractory to vitrectomy with membrane peeling, prior to electing graft surgery. The remaining patient was treatment naïve. Best-corrected visual acuity (BCVA) and parafoveal anatomy were assessed by spectral-domain optical coherence tomography (SD-OCT) at minimum 6 post-operative monthsResults: – All 3 patients successfully completed epiretinal human amniotic membrane graft surgery with anatomic hole closure and partial reconstitution of parafoveal anatomy evident by SD-OCT. BCVA improved in all cases from baseline (range: 20/400 – 20/150) to last post-operative visit (range: 20/125 – 20/70).Conclusion: – MacTel remains a challenging neurodegenerative condition with limited surgical options for complications including macular hole. Epiretinal human amniotic membrane graft could be a viable surgical approach for obtaining macular hole closure, improving vision, and restoring substantial parafoveal anatomy in the appropriate clinical context and warrants additional consideration.