The effects of bupivacaine combined with different adjuvants on block onset and duration and on ion channel expressions (SCN9A, TRPM) in sciatic nerve block in rats

Dolu N., Sahin L., KAPLAN D. S., DEMİR T., Simsek H., Sahin M., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.46, sa.3, ss.926-935, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3906/sag-1502-4
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.926-935
  • Anahtar Kelimeler: Sciatic nerve block, bupivacaine, TRPM, rat, LOCAL-ANESTHETICS, MG2+ HOMEOSTASIS, CLONIDINE, DEXMEDETOMIDINE, EPINEPHRINE, PHARMACOKINETICS, NEUROTOXICITY, ROPIVACAINE, MECHANISM, ANALGESIA
  • Gazi Üniversitesi Adresli: Evet

Özet

Background/aim: The objective of this experimental study was to examine the effects of epinephrine, dexmedetomidine, and clonidine added as adjuvants to bupivacaine on block onset and effect times, as well as the effects on the Na+ and Ca+ 2 channel gene expressions, which may indicate cell damage in the sciatic nerve cell membrane.