The effects of bupivacaine combined with different adjuvants on block onset and duration and on ion channel expressions (SCN9A, TRPM) in sciatic nerve block in rats


Dolu N., Sahin L., KAPLAN D. S. , DEMİR T., Simsek H., Sahin M., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.46, ss.926-935, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 46 Konu: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3906/sag-1502-4
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Sayfa Sayıları: ss.926-935

Özet

Background/aim: The objective of this experimental study was to examine the effects of epinephrine, dexmedetomidine, and clonidine added as adjuvants to bupivacaine on block onset and effect times, as well as the effects on the Na+ and Ca+ 2 channel gene expressions, which may indicate cell damage in the sciatic nerve cell membrane.