The effects of bupivacaine combined with different adjuvants on block onset and duration and on ion channel expressions (SCN9A, TRPM) in sciatic nerve block in rats

Dolu, Nurgul; Sahin, Levent; KAPLAN, DAVUT; DEMİR, TUNCER; Simsek, Hasan; Sahin, Mehrican; Cengiz, Beyhan

doi:10.3906/sag-1502-4

The effects of bupivacaine combined with different adjuvants on block onset and duration and on ion channel expressions (SCN9A, TRPM) in sciatic nerve block in rats

Atıf İçin Kopyala

Dolu N., Sahin L., KAPLAN D. S. , DEMİR T., Simsek H., Sahin M., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.46, ss.926-935, 2016 (SCI İndekslerine Giren Dergi)

Cilt numarası: 46 Konu: 3
Basım Tarihi: 2016
Doi Numarası: 10.3906/sag-1502-4
Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
Sayfa Sayıları: ss.926-935

Özet

Background/aim: The objective of this experimental study was to examine the effects of epinephrine, dexmedetomidine, and clonidine added as adjuvants to bupivacaine on block onset and effect times, as well as the effects on the Na+ and Ca+ 2 channel gene expressions, which may indicate cell damage in the sciatic nerve cell membrane.