Evaluation of an Aqueous-Ethanolic Extract from Rosmarinus officinalis (Rosemary) for its Activity on the Hormonal and Cellular Function of Testes in Adult Male Rat

Heidari-Vala H., Hariry R. E., Sadeghi M. R., Akhondi M. M., Novin M. G., Heidari M.

IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, cilt.12, sa.2, ss.445-451, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 2
  • Basım Tarihi: 2013
  • Dergi Adı: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.445-451
  • Anahtar Kelimeler: Sperm, Testosterone, Rosmarinus officinalis, Rat, Extract, CARNOSIC ACID, CONSTITUENTS, SPERMATOGENESIS, TESTOSTERONE, ANTIOXIDANT, LAMIACEAE, L.
  • Gazi Üniversitesi Adresli: Evet

Özet

Rosmarinus officinalis has been used in traditional medicine extensively. This study evaluated the hormonal and cellular effects of Rosmarinus officinalis extract on testes of adult rats. Thirty male Wistar rats (in three groups) received 50 or 100 mg/Kg b.w of Rosmarinus officinalis extract (made from the plant's leaves, flower and stem) (treatment groups) and 10 mL/Kg b.w normal saline (control group) respectively, on a daily bases by gavage route for 60 days. Then, spermatological properties, histometric parameters and sperm dynamics, testis and body weight, testicular cell population and serum testosterone level were analyzed by an acceptable method.