Objective: The aim of this study was to examine the relation between the functional independence and health related quality of life (HRQoL) in children with chronically disabled. Material and Methods: 78 children and their mothers were included in the study. After taking sociodemographic in formation, the Child Health Questionnaire Parent Form (CHQ-PF50) was used to assess (HRQoL) and functional independence measuring (WeeFIM), was used to evaluate functional independence levels. Results: The age average of children was found to be 7.60 ± 3.43 years. 46 of the children (59%) were diagnosed as cerebral palsy, 6 had (7.7%) muscle disease, and 26 (33.3%) had mental motor retardation. Lowest values in quality of life and level of independence were obtained in children with muscle disease and in children with cerebral palsy, respectively. There were positive correlations between WeeFIM and total CHQ and between WeeFIM and subsections of CHQ except physical function, pain and discomfort and mental health (p< 0.05). There were no differences between CHQ and WeeFIM when the groups were compared (p> 0.05). Conclusion: The results of this study showed a clear relation between functional status and health related quality of life. In addition, although no significant correlation can be showed children with muscle disease had the lowest quality of life. Also, familial compliance parameter was found to be most effected from quality of life. More studies are needed investigating the effects of level of independence on health related quality of life in children with different chronic disabilities. Copyright © 2011 by Türkiye Klinikleri.