Flavonoids with antinociceptive and anti-inflammatory activities from the leaves of Tilia argentea (silver linden)

Toker G., Kupeli E., Memisoglu M., Yesilada E.

JOURNAL OF ETHNOPHARMACOLOGY, vol.95, pp.393-397, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 95
  • Publication Date: 2004
  • Doi Number: 10.1016/j.jep.2004.08.008
  • Page Numbers: pp.393-397
  • Keywords: Tilia argentea, anti -inflammatory, antinociceptive, flavonoids, DESF-EX-DC, QUERCETIN


Silver linden, Tilia argentea Desf. ex DC (Tiliaceae) leaves are used in the treatment of common cold and bronchitis. In order to evaluate this information, antinociceptive and anti-inflammatory activities of the two main flavonoid glycosides: kaempferol-3,7-0-alpha-dirhamnoside and quercetin-3,7-0-alpha-dirhamnoside isolated from the leaves, were investigated. For the antinociceptive activity, p-benzoquinone-induced writhing test and for the anti-inflammatory activity, carrageenan-induced hind paw edema model in mice were used. Both compounds were shown to possess potent antinociceptive and anti-inflammatory activity at 50 mg/kg dose, per os, without inducing any apparent acute toxicity as well as gastric damage. (C) 2004 Elsevier Ireland Ltd. All rights reserved.