Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L.

Kupeli E., Erdemoglu N., Yesilada E., Sener B.

JOURNAL OF ETHNOPHARMACOLOGY, cilt.89, ss.265-270, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 89
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/j.jep.2003.09.005
  • Sayfa Sayıları: ss.265-270


Four taxoids (taxusin, baccatin VI,baccatin III and 1beta-hydroxybaccatin I) and five lignans (lariciresinol, taxiresinol, 3'-demethylisolariciresinol-9'-hydroxyisopropyl ether, isolariciresinol and 3-demethylisolariciresinol) were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-inflammatory and antinociceptive activity of these compounds were investigated. All the compounds were shown to possess significant antinociceptive activity against p-benzoquinone-induced abdominal contractions, while only lignan derivatives significantly inhibited carrageenan-induced hind paw edema in mice. (C) 2003 Elsevier Ireland Ltd. All rights reserved.