Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L.
JOURNAL OF ETHNOPHARMACOLOGY, cilt.89, ss.265-270, 2003 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 89
- Basım Tarihi: 2003
- Doi Numarası: 10.1016/j.jep.2003.09.005
- Dergi Adı: JOURNAL OF ETHNOPHARMACOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.265-270
- Anahtar Kelimeler: anti-inflammatory, antinociceptive, lignans, Taxaceae, taxoids, Taxus spec, CONSTITUENTS, PLANT
- Gazi Üniversitesi Adresli: Evet
Özet
Four taxoids (taxusin, baccatin VI,baccatin III and 1beta-hydroxybaccatin I) and five lignans (lariciresinol, taxiresinol, 3'-demethylisolariciresinol-9'-hydroxyisopropyl ether, isolariciresinol and 3-demethylisolariciresinol) were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-inflammatory and antinociceptive activity of these compounds were investigated. All the compounds were shown to possess significant antinociceptive activity against p-benzoquinone-induced abdominal contractions, while only lignan derivatives significantly inhibited carrageenan-induced hind paw edema in mice. (C) 2003 Elsevier Ireland Ltd. All rights reserved.