Akademik Veri Yönetim Sistemi
Selçuk Tıp Dergisi, cilt.39, sa.1, ss.35-40, 2023 (Hakemli Dergi)
Aim: Melatonin has been found to have anticonvulsant and neuroprotective properties by regulating the circadian rhythm. Based on this effect, it was aimed to determine the serum levels of melatonin in patients with juvenile myoclonic epilepsy (JME) and healthy individuals. It is also the first study to compare serum melatonin levels in patients with JME and healthy individuals. Patients and Methods: Thirty patients with JME and 30 healthy controls with similar gender and age distribution were included in this cross-sectional study. Venous blood samples were taken from patients with JME and healthy individuals to determine the peak serum melatonin level at night and the lowest serum melatonin level in the morning, and studied with the ELIS A method. Results: Compared to healthy controls, serum MELn (p = 0.002) and MELm (p = 0.001) levels of JME patients were determined to be lower than healthy controls. Moreover, there were statistically significant differences between MELn/MELm ratio and MELn-MELm difference between patients with JME and the control group (p = 0.005 and 0.014, respectively). Conclusion: The results show that the circadian rhythm of melatonin is preserved in the patients with JME and the control group, but the serum melatonin levels in the patients are lower than in the controls. Therefore, the determination of melatonin level in patients with JME may contribute to both the determination of the etiology of the disease and the prevention of unnecessary and high-dose antiepileptic drug use by supplementing with melatonin when necessary .