Could the long-term oncological safety of laparoscopic surgery in low-risk endometrial cancer also be valid for the high–intermediate-and high-risk patients? A multi-center turkish gynecologic oncology group study conducted with 2745 endometrial cancer cases. (trsgo-end-001)


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VARDAR M. A., GÜZEL A. B., TAŞKIN S., Gungor M., ÖZGÜL N., Salman C., ...More

Current Oncology, vol.28, no.6, pp.4328-4340, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.3390/curroncol28060368
  • Journal Name: Current Oncology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.4328-4340
  • Keywords: high-risk endometrial cancer, laparoscopic surgery, survival, MINIMALLY INVASIVE SURGERY, ABDOMINAL HYSTERECTOMY, UTERINE-CANCER, EARLY-STAGE, LAPAROTOMY, SURVIVAL, LYMPHADENECTOMY, WOMEN, METAANALYSIS
  • Gazi University Affiliated: Yes

Abstract

© 2021 by the authors. Licensee MDPI, Basel, Switzerland.This study was conducted to compare the long-term oncological outcomes of laparotomy and laparoscopic surgeries in endometrial cancer under the light of the 2016 ESMO-ESGO-ESTRO risk classification system, with particular focus on the high–intermediate-and high-risk categories. Using multicentric databases between January 2005 and January 2016, disease-free and overall survivals of 2745 endometrial cancer cases were compared according to the surgery route (laparotomy vs. laparoscopy). The high–intermediate-and high-risk patients were defined with respect to the 2016 ESMO-ESGO-ESTRO risk classification system, and they were analyzed with respect to differences in survival rates. Of the 2745 patients, 1743 (63.5%) were operated by laparotomy, and the remaining were operated with laparoscopy. The total numbers of high–intermediate- and high-risk endometrial cancer cases were 734 (45%) patients in the laparotomy group and 307 (30.7%) patients in the laparoscopy group. Disease-free and overall survivals were not statistically different when compared between laparoscopy and laparotomy groups in terms of low-, intermediate-, high–intermediateand high-risk endometrial cancer. In conclusion, regardless of the endometrial cancer risk category, long-term oncological outcomes of the laparoscopic approach were found to be comparable to those treated with laparotomy. Our results are encouraging to consider laparoscopic surgery for high–intermediate- and high-risk endometrial cancer cases.