Research Information System
Thesis Type: Postgraduate
Institution Of The Thesis: Gazi Üniversitesi, Fen Bilimleri Enstitüsü, Turkey
Approval Date: 2014
Student: FATİH MEHMET YILMAZ
Supervisor: YUSUF KALENDER
Open Archive Collection: AVESIS Open Access Collection
Abstract:Mercury chloride as a heavy metal with a harmful effect on humans and animals are described. In this study, sodium selenite, vitamin E, vitamin E+sodium selenite, mercuric chloride, sodium selenite+mercuric chloride, vitamin E+mercuric chloride and sodium selenite+vitamin E+mercuric chloride were given to male rats through gavage. After 4 weeks of treatment rats were examined under the light microscope and the histopathological changes occurring in the thyroid as compared with the control group were investigated. Some histopathological changes were detected in thyroid tissue in mercuric chloride treated group, less histopathological changes were observed in sodium selenite+mercuric chloride, vitamin E+mercuric chloride and sodium selenite+vitamin E+mercuric chloride treated groups. As a result, sodium selenite, vitamin E and vitamin E+sodium selenite significantly reduce mercuric chloride induced thyrotoxicity in rats, but not protect completely.