Research Information System
Thesis Type: Postgraduate
Institution Of The Thesis: Gazi University, Sağlık Bilimleri Enstitüsü, Turkey
Approval Date: 2007
Thesis Language: Turkish
Student: Nazan IŞIK
Supervisor: FATMA ERGUN
Abstract:Anxiety, is one of the common mental disturbances that affects human being and because of the increase in its frequency, it affects the social life negatively. The drug used in the cure such as benzodazephine, buspirone can cause dependency, disturbance in psychomotor functions, decrease in physical performance and and side effects after leaving drug use; therefore new alternative approaches have come into view. In this research we searched the frequently used herbals in the treatment of anxiety such as Passiflora incarnata, Valeriana officinalis ve Melissa officinalis. We examined the pharmacological and clinical studies about these herbals, their effect mechanismes and medical use and give examples for the commercial forms of preparates. Even if the effect mechanisms of some herbals such as Passiflora incarnata ve Melissa officinalis has not been identified exactly, the idea that Valeriana officinalis affected by having a role in the enzimatic disturbance of GABA have been important. As a results of pharmocological researches, it has been shown that Passiflora incarnata had sedative, hipnotic and anxiolytic effects and and accepted it could be used in removing anxiety and sleep disorders with its commercial preparates. But there are few pharmacological and clinical studies related to Melissa officinalis. In these researches the hipnotic and anxiolytic effectiveness of this herbal has been defined but was seen that this effectiveness in the combination preparates was higher. Its use in aromoteraphy is succesful and it is considered that the terpens in essential oils cause this effect. There are lots of studies about that Valeriana officinalis s use is very succesful especially in the long term treatment of sleep disorders as a hipnotic and anxiolytic agent. By providing synergy in the combination products of the each of these three products, succesfull results have come into view. Compared to other chemicals, it is more reliable because of few side effects. And also İt has some superioties because it is tolerated easily, it doesn t cause to dependency and affect daily performance. As a result of this research, attention has been paid to warnings about the choice of qualified, effective herbal products, the dosage, occupancy and the interaction of them with other drugs in order to progress the consciousness of the user.