Publications

Articles

<i>In silico</i> approach reveals <i>N</i>-(5-phenoxythiophen-2-yl)-2-(arylthio)acetamides as promising selective SIRT2 inhibitors: the case of structural optimization of virtual screening-derived hits

GÖZELLE M., BAKAR ATEŞ F., Massarotti A., Ozkan E., Gunindi H. B., ÖZKAN Y., et al.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, vol.43, no.4, pp.1756-1767, 2025 (SCI-Expanded) identifier identifier identifier

Selective inhibition of SIRT2: A disputable therapeutic approach in cancer therapy

KAYA S. G., EREN G.
BIOORGANIC CHEMISTRY, vol.143, pp.107038-0, 2024 (SCI-Expanded) identifier identifier identifier

Field-based 3D-QSAR studies on amide- and urea-containing NAMPT inhibitors

ÖZGENCİL F., EREN G.
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, vol.242, 2023 (SCI-Expanded) Sustainable Development identifier identifier

Hit evaluation results in 5-benzyl-1,3,4-thiadiazole-2-carboxamide based SIRT2-selective inhibitor with improved affinity and selectivity

Gözelle M., Kaya S. G., Aksel A. B., Özkan E., Bakar Ateş F., Özkan Y., et al.
Bioorganic Chemistry, vol.123, pp.105746, 2022 (SCI-Expanded) Sustainable Development identifier identifier identifier

The potential of 4-aryl-6-morpholino-3(2H)-pyridazinone-2-arylpiperazinylacetamide as a new scaffold for SIRT2 inhibition: in silico approach guided by pharmacophore mapping and molecular docking

ŞÜKÜROĞLU M. K., GÖZELLE M., ÖZKAN Y., EREN G.
MEDICINAL CHEMISTRY RESEARCH, vol.30, no.10, pp.1915-1924, 2021 (SCI-Expanded) Sustainable Development identifier identifier

Hit-to-lead optimization on aryloxybenzamide derivative virtual screening hit against SIRT

Yagci S., Gözelle M., Kaya S. G., Özkan Y., Aksel A. B., Bakar-Ates F., et al.
BIOORGANIC & MEDICINAL CHEMISTRY, vol.30, 2021 (SCI-Expanded) Sustainable Development identifier identifier identifier

Identification of small-molecule urea derivatives as novel NAMPT inhibitors via pharmacophore-based virtual screening

Ozgencil F., EREN G., ÖZKAN Y., GÜNTEKİN ERGÜN S., ATALAY R.
BIOORGANIC & MEDICINAL CHEMISTRY, vol.28, no.1, 2020 (SCI-Expanded) Sustainable Development identifier identifier identifier

Pharmacophore modeling and virtual screening studies to identify novel selective SIRT2 inhibitors

Eren G., Bruno A., Guntekin-Ergun S., Atalay R., Ozgencil F., Özkan Y., et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, vol.89, pp.60-73, 2019 (SCI-Expanded) Sustainable Development identifier identifier identifier

Homology Modeling of Human Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2: Insights into Isoenzyme-Specific Differences Using Molecular Docking Simulatons

EREN G.
LETTERS IN DRUG DESIGN & DISCOVERY, vol.14, no.6, pp.727-736, 2017 (SCI-Expanded) Sustainable Development identifier identifier

Papers Published in Refereed Scientific Meetings

SIRT2 Inhibitory Activities of N-Aryloxyphenyl-2-(arylthio)acetamide Derivatives

KAYA S. G., ÖZKAN Y., EREN G.
GPSS-2021, 3rd International Gazi Pharma Symposium Series, Turkey, 8 - 10 September 2021, (Summary Text)

Design and Synthesis of Aryloxy Benzamide Derivatives with Potential Inhibitory Effect against SIRT2

YAGCI S., GÖZELLE M., KAYA S. G., EREN G.
EFMC-YMCS, 6th EFMC Young Medicinal Chemist Symposium, 5 - 06 September 2019, (Summary Text)

N-(5-Arylmethyl-1,3,4-oxadiazole-2-yl)-2-(arylthio)acetamide as a New Scaffold for Developing Small-molecule SIRT Inhibitors

AKSEL A. B., ÖZKAN Y., EREN G.
GPSS-2021, 3rd International Gazi Pharma Symposium Series, Turkey, 8 - 10 September 2021, (Summary Text)

Discovery of 5-Benzyl-1,3,4-oxadiazole/thiadiazole-2-carboxamides as Potential Leads for Selective SIRT2 Inhibition

GÖZELLE M., ÖZKAN Y., EREN G.
GPSS-2021, 3rd International Gazi Pharma Symposium Series, Ankara, Turkey, 8 - 10 September 2021, (Summary Text)

Homology Modeling of Human Nicotinamide Mononucleotide Adenylyltransferase 2 Insights into Isoenzyme Specific Differences Using Molecular Docking Simulations

GOZELLE M., EREN G.
21st EuroQSAR, Where Molecular Simulations Meet Drug Discovery, 4 - 08 October 2016, (Summary Text)

3D-QSAR Studies on Amide and Urea Derivatives as NAMPT Inhibitors

ÖZGENCİL F., EREN G.
9th EFMC Young Medicinal Chemists' Symposium (EFMC-YMCS 2022), Nice, France, 8 - 09 September 2022, (Summary Text)

HOMOLOGY MODELING OF HUMAN NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE 2 INSIGHTS INTO ISOENZYME SPECIFIC DIFFERENCES USING MOLECULAR DOCKING SIMULATIONS

GÖZELLE M., EREN G.
21st EuroQSAR, Verona, Italy, 4 - 08 September 2016, (Summary Text)

N-(5-(3-Methoxybenzyl)/(pyrimidin-2-yl-methyl))-1,3,4-oxadiazol-2-yl)-2-(arylthio)acetamide Derivatives as SIRT2 Inhibitors

AKSEL A. B., ÖZKAN Y., EREN G.
9th EFMC Young Medicinal Chemists' Symposium (EFMC-YMCS 2022), Nice, France, 8 - 09 September 2022, (Summary Text)

Pharmacophore Based Virtual Screening to Identify Novel SIRT2 Inhibitors

EREN G., BRUNO A., COSTANTINO G.
21st EuroQSAR, Where Molecular Simulations Meet Drug Discovery, 4 - 08 October 2016, (Summary Text)

In Silico Hit Optimization toward SIRT2 Inhibition: N-aryloxyaryl-2-(arylthio)acetamides

KAYA S. G., ÖZKAN Y., EREN G.
9th EFMC Young Medicinal Chemists' Symposium (EFMC-YMCS 2022), Nice, France, 8 - 09 September 2022, (Summary Text)

Ariloksi Benzamit Yapısında Sirtuin İnhibitörü Olabilecek Bileşiklerin Tasarımı, Sentezi ve Biyolojik Aktivite Çalışmaları

YAĞCI S., GÖZELLE M., ÖZKAN Y., BAKAR ATEŞ F., EREN G.
VI. Ulusal Farmasötik Kimya Kongresi, İstanbul, Turkey, 26 - 29 August 2022, (Summary Text)

Yeni Nikotinamit Fosforiboziltransferaz (NAMPT) İnhibitör Adaylarının Sanal Tarama Yöntemi ile Keşfi ve Biyolojik Etkilerinin Belirlenmesi

ÖZGENCİL F., ÖZKAN Y., EREN G.
VI. Ulusal Farmasötik Kimya Kongresi, İstanbul, Turkey, 26 - 29 August 2022, (Summary Text)