Inhibitory Effects of the Active Components Isolated from Satureja Boissieri Hausskn. Ex Boiss. On Human Cervical Cancer Cell Line


ÖKE ALTUNTAŞ F., DEMİRTAŞ İ., TÜFEKÇİ A. R. , KOLDAŞ S., GÜL F., BEHÇET L., ...More

JOURNAL OF FOOD BIOCHEMISTRY, vol.40, no.4, pp.499-506, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1111/jfbc.12238
  • Journal Name: JOURNAL OF FOOD BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.499-506
  • Gazi University Affiliated: Yes

Abstract

The aim of this study was to isolate the active components from the essential oil (EO) of Satureja boissieri and to investigate the cytotoxic effects of these components on human cervical epithelioid carcinoma (HeLa) cell line. The major components of EO were found to be p-cymene (23.15%), -terpinene (22.84%), thymol (18.96%) and carvacrol (21.25%) using GC-MS. The components were separated by column chromatography and p-cymene, thymol and spathulenol were isolated as pure terpenoids. The cytotoxic activity of the components was investigated using the xCELLigence system (Real Time Cell Analyzer). The pure compounds, p-cymene and thymol exhibited excellent cytotoxic effects against HeLa cell line.