Electrospinning of cyclodextrin/linalool-inclusion complex nanofibers: Fast-dissolving nanofibrous web with prolonged release and antibacterial activity

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Aytac Z., Yildiz Z. I., Kayaci-Senirmak F., Tekinay T., UYAR T.

FOOD CHEMISTRY, cilt.231, ss.192-201, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 231
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.foodchem.2017.03.113
  • Dergi Adı: FOOD CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.192-201
  • Anahtar Kelimeler: Antibacterial activity, Cyclodextrin, Electrospinning, Nanofibers, Inclusion complex, Linalool, Nanofiber, Release, POLYMER-FREE NANOFIBERS, HIGH THERMAL-STABILITY, ANTIMICROBIAL ACTIVITY, ANTIOXIDANT ACTIVITY, DRUG-DELIVERY, ESSENTIAL OIL, SHELF-LIFE, ENCAPSULATION, FILTRATION, LINALOOL
  • Gazi Üniversitesi Adresli: Evet

Özet

The volatility and limited water solubility of linalool is a critical issue to be solved. Here, we demonstrated the electrospinning of polymer-free nanofibrous webs of cyclodextrin/linalool-inclusion complex (CD/linalool-IC-NFs). Three types of modified cyclodextrin (HP beta CD, M beta CD, and HP gamma CD) were used to electrospin CD/linalool-IC-NFs. Free-standing CD/linalool-IC-NFs facilitate maximum loading of linalool up to 12% (w/w). A significant amount of linalool (45-89%) was preserved in CD/linalool-IC-NFs, due to enhancement in the thermal stability of linalool by cyclodextrin inclusion complexation. Remarkably, CD/linalool-IC-NFs have shown fast-dissolving characteristics in which these nanofibrous webs dissolved in water within two seconds. Furthermore, linalool release from CD/linalool-IC-NFs inhibited growth of model Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria to a great extent. Briefly, characteristics of liquid linalool have been preserved in a solid nanofiber form and designed CD/linalool-IC-NFs confer high loading capacity, enhanced shelf life and strong antibacterial activity of linalool. (C) 2017 Elsevier Ltd. All rights reserved.