Assessment of Anti-Inflammatory and Antinociceptive Activities of Olea europaea L.

SÜNTAR İ. , AKKOL E. , Baykal T.

JOURNAL OF MEDICINAL FOOD, cilt.13, sa.2, ss.352-356, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Konu: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1089/jmf.2009.0067
  • Sayfa Sayıları: ss.352-356


Leaves and fruits of Olea europaea L. (Family Oleaceae) are used for the treatment of various kinds of diseases, i.e., rheumatism and hemorrhoids, and as a vasodilator in vascular disorders for ages in folk medicine. In order to evaluate this information, anti-inflammatory and antinociceptive activities of the ethanolic and n-hexane extracts prepared from the fruits of O. europaea were investigated. For the anti-inflammatory activity, the carrageenan-induced hind paw edema and acetic acid-induced increased capillary permeability models were used, and for the antinociceptive activity, the p-benzoquinone-induced writhing and hot plate tests in mice were used. The results revealed that the ethanolic extract did not show a significant anti-inflammatory or analgesic activity, whereas the n-hexane extract displayed 12.7-27.8% inhibition on the carrageenan-induced hind paw edema model at the 400 mg/kg dose, without inducing any apparent acute toxicity as well as gastric damage. Further studies are warranted to define and isolate the active anti-inflammatory and antinociceptive components from this plant, which may yield safe and effective agents to be used in the treatment of inflammatory disorders.