In the present study, it was aimed to investigate the antioxidant and antigenotoxic effects of Lycoperdon molle Pers., one of the important edible mushroom species, on cultured human peripheral lymphocytes. Total oxidant status (TOS) and total antioxidant capacity (TAC) changes in the cells treated with different concentrations (1-100 mg/L) of methanol (LMME) and water (LMWE) extracts from dried fresh L. molle were tested. In the results of these analyses determined that the concentration of 100 mg/L of LMME and LMWE increased the TOS ratio in the cells at the level of p < 0.05 compared to the negative control. TAC levels caused by the applications of both extracts with 125 mg/L concentration were found to be higher than the TAC ratio, revealed by the negative control group. The levels of genetic damage of the respective extracts on the cells were determined by micronucleus (MN) and chromosome aberration (CA) tests. In both extract groups revealed that MN and CA frequencies which were caused by experiments other than 50 and 100 mg/L concentrations were not statistically ( p > 0.05) different from negative control.