High-fructose corn syrup-induced hepatic dysfunction in rats: improving effect of resveratrol

SADİ G., Ergin V., Yilmaz G., Pektas M. B. , Yildirim O. G. , Menevse A., ...Daha Fazla

EUROPEAN JOURNAL OF NUTRITION, cilt.54, sa.6, ss.895-904, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Konu: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s00394-014-0765-1
  • Dergi Adı: EUROPEAN JOURNAL OF NUTRITION
  • Sayfa Sayıları: ss.895-904

Özet

The increased consumption of high-fructose corn syrup (HFCS) may contribute to the worldwide epidemic of fatty liver. In this study, we have investigated whether HFCS intake (20 % beverages) influences lipid synthesis and accumulation in conjunction with insulin receptor substrate-1/2 (IRS-1; IRS-2), endothelial nitric oxide synthase (eNOS), sirtuin 1 (SIRT1) and inducible NOS (iNOS) expressions in liver of rats. Resveratrol was tested for its potential efficacy on changes induced by HFCS.