High-fructose corn syrup-induced hepatic dysfunction in rats: improving effect of resveratrol

SADİ, GÖKHAN; Ergin, Volkan; Yilmaz, Guldal; Pektas, M.; Yildirim, O.; Menevse, Adnan; AKAR, FATMA

doi:10.1007/s00394-014-0765-1

High-fructose corn syrup-induced hepatic dysfunction in rats: improving effect of resveratrol

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SADİ G., Ergin V., Yilmaz G., Pektas M. B. , Yildirim O. G. , Menevse A., ...More

EUROPEAN JOURNAL OF NUTRITION, vol.54, no.6, pp.895-904, 2015 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 54 Issue: 6
Publication Date: 2015
Doi Number: 10.1007/s00394-014-0765-1
Title of Journal : EUROPEAN JOURNAL OF NUTRITION
Page Numbers: pp.895-904

Abstract

The increased consumption of high-fructose corn syrup (HFCS) may contribute to the worldwide epidemic of fatty liver. In this study, we have investigated whether HFCS intake (20 % beverages) influences lipid synthesis and accumulation in conjunction with insulin receptor substrate-1/2 (IRS-1; IRS-2), endothelial nitric oxide synthase (eNOS), sirtuin 1 (SIRT1) and inducible NOS (iNOS) expressions in liver of rats. Resveratrol was tested for its potential efficacy on changes induced by HFCS.