Acetylcholinesterase inhibitory and antioxidant properties of Cyclotrichium niveum, Thymus praecox subsp. caucasicus var. caucasicus, Echinacea purpurea and E. pallida

Orhan İ., Senol F. S., Guelpinar A. R., Kartal M., Sekeroglu N., Deveci M., ...Daha Fazla

Food and Chemical Toxicology, cilt.47, sa.6, ss.1304-1310, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 6
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.fct.2009.03.004
  • Dergi Adı: Food and Chemical Toxicology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1304-1310
  • Anahtar Kelimeler: Cyclotrichium niveum, Thymus praecox subsp caucasicus var. caucasicus, Echinacea, Essential oil, Acetylcholinesterase inhibition, Antioxidant activity, ESSENTIAL OILS, CHEMICAL-COMPOSITION, ANTICHOLINESTERASE, EXTRACTS, SALVIA, DERIVATIVES
  • Gazi Üniversitesi Adresli: Evet

Özet

The dichloromethane, ethyl acetate, ethanol, and aqueous extracts of Cyclotrichium niveum (CN) and Thymus praecox subsp. caucasicus var. caucasicus (TP), Echinacea purpurea (EPU), and E. pallida (EPA) along with the essential oils of CN and TP were assessed for their anti-acetylcholinesterase (AChE) and antioxidant activities. AChE inhibition was estimated using spectrophotometric method of Ellman. Antioxidant activity was evaluated by 2,2-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and ferrous ion-chelating power tests. Ferric-reducing antioxidant power (FRAP) of CN and TP were also tested. CN essential oil was found to contain isomenthone (56.21%) and pulegone (19.76%). The ethyl acetate (83.11-87.98%) and dichloromethane (73.45-84.02%) extracts of CN showed the highest AChE inhibition. The ethyl acetate and ethanol extracts of TP exerted significant DPPH scavenger effect. The water extracts of CN and TP and the chloroform extract of the aerial parts of EPU displayed the highest ferrous ion-chelating effect. The leaf and flower essential oils of TP had the best FRAP. © 2009 Elsevier Ltd. All rights reserved.