Asst. Prof. ABDURRAHMAN OLĞAÇ

Publication Network

Published journal articles indexed by SCI, SSCI, and AHCI

Quinazoline-4(3H)-one-7-carboxamide Derivatives as Human Soluble Epoxide Hydrolase Inhibitors with Developable 5-Lipoxygenase Activating Protein Inhibition

TURANLİ S., Ergul A. G., Jordan P. M., OLĞAÇ A., ÇALIŞKAN B., Werz O., et al.

ACS OMEGA, vol.7, no.41, pp.36354-36365, 2022 (SCI-Expanded)

Discovery and Optimization of Piperazine Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors.

Çapan İ., Jordan P. M., Olğaç A., Çalışkan B., Kretzer C., Werz O., et al.

ChemMedChem, vol.17, no.12, 2022 (SCI-Expanded)

Design and synthesis of novel substituted indole-acrylamide derivatives and evaluation of their anti-cancer activity as potential tubulin-targeting agents

Hawash M., KAHRAMAN D. C., OLĞAÇ A., Ergun S. G., Hamel E., Cetin-Atalay R., et al.

Journal of Molecular Structure, vol.1254, 2022 (SCI-Expanded) Sustainable Development

Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase

Ergül A. G., Maz T. G., Kretzer C., Olğaç A., Jordan P. M., Çalışkan B., et al.

European Journal of Medicinal Chemistry, vol.231, 2022 (SCI-Expanded) Sustainable Development

Identification of Novel Antiplatelet Agents by Targeting Glycoprotein VI: A Combined Virtual Screening Study

Olğaç S., Olğaç A., Yenicesu İ., Özkan Y.

Bioorganic Chemistry, vol.121, pp.1-11, 2022 (SCI-Expanded) Sustainable Development

Simple heteroaryl modifications in the 4,5-diarylisoxazol-3-carboxylic acid scaffold favorably modulates the activity as dual mPGES-1/5-LO inhibitors with in vivo efficacy

Gurses T., OLĞAÇ A., Garscha U., GÜR MAZ Z. T., BAL N. B., Uludag O., et al.

BIOORGANIC CHEMISTRY, vol.112, 2021 (SCI-Expanded)

Discovery of Novel 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors by Exploiting a Multistep Virtual Screening Protocol

OLĞAÇ A., Carotti A., Kretzer C., Zergiebel S., Seeling A., Garscha U., et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING, vol.60, no.3, pp.1737-1748, 2020 (SCI-Expanded)

Ortho versus Meta Chlorophenyl-2,3-Benzodiazepine Analogues: Synthesis, Molecular Modeling, and Biological Activity as AMPAR Antagonists

Qneibi M., Jaradat N., Hawash M., OLĞAÇ A., Emwas N.

ACS OMEGA, vol.5, no.7, pp.3588-3595, 2020 (SCI-Expanded)

The 12(th) AFMC International Medicinal Chemistry Symposium (AIMECS 2019) in Istanbul, Turkey

OLĞAÇ A., Yalcin I., Aki-Yalcin E.

CHEMMEDCHEM, vol.15, no.1, pp.162-167, 2020 (SCI-Expanded)

Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors

Boccellino M., Donniacuo M., Bruno F., Rinaldi B., Quagliuolo L., Ambruosi M., et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.180, pp.637-647, 2019 (SCI-Expanded) Sustainable Development

Structural insight into the optimization of ethyl 5-hydroxybenzo[g] indol-3-carboxylates and their bioisosteric analogues as 5-LO/mPGES-1 dual inhibitors able to suppress inflammation

Bruno F., Errico S., Pace S., Nawrozkij M. B., Mkrtchyan A. S., Guida F., et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.155, pp.946-960, 2018 (SCI-Expanded)

Identification of multi-target inhibitors of leukotriene and prostaglandin E-2 biosynthesis by structural tuning of the FLAP inhibitor BRP-7

GÜR MAZ Z. T., ÇALIŞKAN B., Garscha U., OLĞAÇ A., Schubert U. S., Gerstmeier J., et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.150, pp.876-899, 2018 (SCI-Expanded) Sustainable Development

The potential role of in silico approaches to identify novel bioactive molecules from natural resources

Olğaç A., Erdoğan Orhan İ., Banoğlu E.

FUTURE MEDICINAL CHEMISTRY, vol.9, no.14, pp.1663-1684, 2017 (SCI-Expanded)

Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7

Levent S., Gerstmeier J., Olğaç A., Nikels F., Garscha U., Carotti A., et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.122, pp.510-519, 2016 (SCI-Expanded) Sustainable Development

4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP)

Banoğlu E., Celikoglu E., Voelker S., Olğaç A., Gerstmeier J., Garscha U., et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.113, pp.1-10, 2016 (SCI-Expanded)

Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors

Baytaş S., Inceler N., Yilmaz A., Olğaç A., Menevse S., Banoğlu E., et al.

BIOORGANIC & MEDICINAL CHEMISTRY, vol.22, no.12, pp.3096-3104, 2014 (SCI-Expanded)

Articles Published in Other Journals

Mitochondrial Haplogroup Distribution in Elite Turkish Athletes

Kurtuluş M., Günay M., Çelenk Ç., Olğaç A., Kesici T.

Niğde Ömer Halisdemir Üniversitesi Beden Eğitimi ve Spor Bilimleri Dergisi, vol.14, no.3, pp.494-502, 2020 (Peer-Reviewed Journal)

Refereed Congress / Symposium Publications in Proceedings

A journey from selective FLAP inhibitor to selective mPGES-1 inhibitor: A new therapeutic modality for reducing inflammation and pain

BANOĞLU E., ÇALIŞKAN B., ERGÜL A. G., GÜR MAZ Z. T., OLĞAÇ A., JORDAN P. M., et al.

8th International Bahçeşehir University (BAU) Drug Design Congress, İstanbul, Turkey, 15 - 17 December 2022

Identification of Novel Microsomal Prostaglandin E2 Type 1 (mPGES-1) Inhibitors by Conducting Structure-based Virtual Screening

Olğaç A., Carotti A., Jordan P. M., Kretzer C., Werz O., Banoğlu E.

International Bioinformatics Conference (IBC 2022), Tanjah, Morocco, 8 - 09 October 2022, pp.17

IDENTIFICATION OF NOVEL MICROSOMAL PROSTAGLANDIN E2 TYPE 1 (mPGES-1) INHIBITORS BY CONDUCTING STRUCTURE-BASED VIRTUAL SCREENING

OLĞAÇ A., Carotti A., Jordan P. M., Kretzer C., Werz O., BANOĞLU E.

23rd European Symposium on Quantitative Structure-Activity Relationship (EuroQSAR), Heidelberg, Germany, 26 September 2022

IDENTIFICATION OF NOVEL SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3) ACTIVE SITES BY MOLECULAR DYNAMICS

Ekinci K., Olğaç A., Akı Yalçın E. E.

23rd European Symposium on Quantitative Structure-Activity Relationship (EuroQSAR), Heidelberg, Germany, 26 September 2022

Novel Microsomal Prostaglandin E2 Synthase-1 (MPGES-1) Inhibitors as a New Modality To Treat Inflammation

ÇALIŞKAN B., ERGÜL A. G., GÜR MAZ Z. T., KRETZER C., OLĞAÇ A., JORDAN P. M., et al.

XXVll EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2022), Nice, France, 4 - 08 September 2022

SELECTIVE OR DUAL INHIBITORS OF INFLAMMATORY PGE2 AND LTB4 BIOSYNTHESIS BY TARGETING mPGES-1 AND FLAP TO INTERVENE WITH INFLAMMATORY DEREGULATION

BANOĞLU E., ÇALIŞKAN B., ERGÜL A. G., GÜR MAZ Z. T., OLĞAÇ A., WERZ O.

The Sixth International Symposium on Pharmaceutical and Biomedical Sciences (ISPBS-6), Gaziantep, Turkey, 26 - 28 May 2022

Discovery of Novel Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors: A New Modality to Treat Inflammation

BANOĞLU E., ÇALIŞKAN B., ERGÜL A. G., GÜR MAZ Z. T., KRETZER C., OLĞAÇ A., et al.

10th International Drug Chemistry Conference, Antalya, Turkey, 10 March - 13 May 2022

Computational Insights into the Binding Pattern of Microsomal Prostaglandin E-2 Synthase Type 1 Inhibitors

Olğaç A., Banoğlu E.

3rd International Gazi Pharma Symposium Series (GPSS-2021), Ankara, Turkey, 8 - 10 September 2021, pp.77 Sustainable Development

Structure-Guided Selection of Suitable Nanoemulsion Formulation Components for a Recombinant Form of Human Interleukin-2 (Aldesleukin)

Olğaç S., Olğaç A., İnceçayır T., Teksin Z. Ş.

3rd International Gazi Pharma Symposium Series (GPSS-2021), Ankara, Turkey, 8 - 10 September 2021

Discovery of Multitarget Inhibitors in the Arachidonic Acid Pathway by Targeting FLAP/5-LO/mPGES-1 for Intervention with Inflammatory Deregulation

BANOĞLU E., ÇALIŞKAN B., GÜR MAZ Z. T., OLĞAÇ A., Garscha U., Werz O.

8th International Drug Chemistry Conference, Antalya, Turkey, 27 February - 01 March 2020

Investigation of the activation mechanisms of natural clotting processes by highly deacetylated chitosan

Elçi S. D., BOLELLİ K., Hidayat A. N., OLĞAÇ A., Javornik U., BELEN APAK F. B., et al.

8th International Drug Chemistry Conference, Antalya, Kemer, Turkey, 27 February - 01 March 2020

An in silico Investigation of the Activation Mechanisms of Clotting Processes by Highly Deacetylated Oligomeric Chitosan

Elçi S. D., Hidayat A. N., OLĞAÇ A., AKI YALÇIN E. E.

Asian Federation for Medicinal Chemistry (AFMC) 12th International Symposium, Ankara, Turkey, 8 - 11 September 2019

Virtual Screening to Discover Drug Candidates Targeting Platelet Receptors

OLĞAÇ S., OLĞAÇ A., YENİCESU İ., ÖZKAN Y.

Asian Federation of Medicinal Chemistry (AFMC) 12th International Symposium, İstanbul, Turkey, 8 - 11 September 2019

Virtual Screening for Small Molecule Inhibitors of Glycoprotein VI (GPVI)

OLĞAÇ S., OLĞAÇ A., ÖZKAN Y.

4th European Platelet Network (EUPLAN), 19 - 21 September 2018

DISCOVERY OF NOVEL 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITORS BY VIRTUAL SCREENING ANDPHARMACOLOGICAL EVALUATION

OLĞAÇ A., CAROTTI A., Garscha U., Werz O., Macchiarulo A., BANOĞLU E.

22nd European Symposium on Quantitative Structure-Activity RelationshipsTranslational and Health Informatics: Implications for Drug Discovery, 16 - 20 September 2018

EVOLUTION OF SELECTIVE FLAP INHIBITOR BRP-7 INTO MULTI-TARGET INHIBITOR OF FLAP, 5-LO AND MPGES-1 IN THE ARACHIDONIC ACID PATHWAY

GÜR MAZ Z. T., ÇALIŞKAN B., OLĞAÇ A., GERSTMEIER J., GARSCHA U., WERZ O., et al.

EFMC International Symposium on Medicinal Chemistry, Ljubljana, Slovenia, 2 - 06 September 2018, pp.231

PROTEIN-LIGAND INTERACTION ANALYSIS THROUGH DOCKING AND MOLECULAR DYNAMIC SIMULATIONS OF KNOWN 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS

OLĞAÇ A., CAROTTI A., Macchiarulo A., BANOĞLU E.

RICT 2018 Interfacing Chemical Biology and Drug Discovery 54th International Conference on Medicinal Chemistry, Strasbourg, France, 4 - 06 July 2018

In Vitro Antiplatelet Studies on Virtually Discovered GPVI Drug Candidates

OLĞAÇ S., Olgaç A., ÖZKAN Y.

12th International Symposium on Pharmaceutical Sciences (ISOPS), 26 - 29 June 2018

ANTİLÖKOTRİEN ETKİLİ 1,2,5-TRİSÜBSTİTÜEBENZİMİDAZOL TÜREVLERİNİN GELİŞTİRİLMESİ ÜZERİNDE YAPILAN ÇALIŞMALAR

GÜR MAZ Z. T., ÇALIŞKAN B., GERSTMEIER J., OLĞAÇ A., GARSCHA U., WERZ O., et al.

V. ULUSAL FARMASÖTİK KİMYA KONGRESİ, Erzurum, Turkey, 28 April - 01 May 2018

SANAL TARAMA VE FARMAKOLOJİK DEĞERLENDİRME YOLUYLA YENİ 5-LİPOKSİJENAZ AKTİVE EDİCİ PROTEİN (FLAP) İNHİBİTÖRÜ BİLEŞİKLERİN KEŞFİ

OLĞAÇ A., CAROTTI A., Garscha U., Werz O., Macchiarulo A., BANOĞLU E.

V. ULUSAL FARMASÖTİK KİMYA KONGRESİ, Erzurum, Turkey, 28 April - 01 May 2018

Cloud-Based High Performance Virtual Screening in Novel Drug Discovery

OLĞAÇ A., Möller S.

WG MC Meeting Fontainebleau (France), Fontainebleau, France, 19 - 20 March 2018

Discovery and Development of Novel Anti-cancer and Anti-inflammatory Compounds: Medicinal Chemistry Challenges

BANOĞLU E., ÇALIŞKAN B., GÜR MAZ Z. T., OLĞAÇ A., İBİŞ K., Akhan Güzelcam E., et al.

The 4th International Symposium on Pharmaceutical and Biomedical Sciences, Kumamoto, Japan, 17 March 2018 Sustainable Development

Investigation of Novel Platelet Receptor GPVI Inhibitor Candidates

OLĞAÇ S., OLĞAÇ A., ÖZKAN Y.

2nd International Gazi Pharma Symposium Series, 11 - 13 October 2017

Discovery of Novel 5-Lipoxygenase Activating Protein (FLAP) Inhibitors by Virtual Screening

OLĞAÇ A., CAROTTI A., GERSTMEIER J., GARSCHA U., WERZ O., MACCHIARULO A., et al.

2nd International Gazi Pharma Symposium Series, 11 - 13 October 2017

Developing Multi-target Inhibitors of Arachidonic Acid Pathway Based on the FLAP Inhibitor BRP-7

GÜR Z. T., ÇALIŞKAN B., GERSTMEIER J., OLĞAÇ A., GARSCHA U., WERZ O., et al.

2nd International Gazi Pharma Symposium Series, 11 - 13 October 2017

Discovery of Dual FLAP/mPGES-1 Inhibitors for Intervention with Inflammatory Diseases:Medicinal Chemistry Challenges

BANOĞLU E., ÇALIŞKAN B., GÜR Z. T., OLĞAÇ A.

Turkish Japanese Workshop on Bioorganic Medicinal Chemistry Natural Products, 14 September 2017

Bioisosteric Tuning of FLAP Inhibitor BRP-7 Towards a More Potent Antiinmlammatory Agent with Multiligand Inhibitor Properties in the Arachidonic Acid (AA) Pathway

GÜR Z. T., ÇALIŞKAN B., OLĞAÇ A., GERSTMEIER J., GARSCHA U., WERZ O., et al.

EFMC-ASMC’xx17 EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry, 27 - 31 August 2017

Discovery of Novel 5-Lipoxygenase Activating Protein (FLAP) Inhibitors by Combined Ligand- and Structure-Based Virtual Screening

OLĞAÇ A., CAROTTI A., GERSTMEIER J., GARSCHA U., WERZ O., MACCHIARULO A., et al.

EFMC-ASMC’xx17 EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry, 27 - 31 August 2017

Araşidonik asit yolağında çoklu ligand (FLAP/5-LO/mPGES-1) özellikte inhibitör etkili BRP-7 türevlerinin geliştirilmesi

BANOĞLU E., GÜR Z. T., ÇALIŞKAN B., GERSTMEIER J., OLĞAÇ A., GARSCHA U., et al.

1. Anadolu Üniversitesi Eczacılık Sempozyumu, Eskişehir, Turkey, 1 - 02 June 2017, pp.10

Structure Based Virtual Screening to Discover Platelet GPVI Inhibitors

OLĞAÇ S., OLĞAÇ A., ÖZKAN Y.

Third European Platelet Network (EUPLAN) Conference 2016, Bad Homburg vor der Höhe, Germany, 21 - 23 September 2016

Structure based virtual screaning to discover platelet GPVI inhibitors

OLĞAÇ S., olgac A., ÖZKAN Y.

The 3rd EUPLAN conference, 21 - 23 September 2016

Screening FDA Approved Drugs to Discover Potent GPVI Inhibitors

OLĞAÇ S., OLĞAÇ A., ÖZKAN Y.

XXIV National Meeting in Medicinal Chemistry, Perugia, Italy, 11 - 14 September 2016

Structure Guided Design of Novel Isoxazole and Benzimidazole Derivatives as Potent 5 Lipoxygenase 5 LO and 5 LO Activating Protein FLAP Inhibitors

OLĞAÇ A., CAROTTI A., WERZ O., BANOĞLU E., MACCHIARULO A.

XXIV National Meeting in Medicinal Chemistry, Perugia, Italy, 11 - 14 September 2016

Evias Web Services Cloud Based Drug Discovery Platform

OLĞAÇ A., BUDAK G., OLĞAÇ S., NUTI R., CAROTTI A., BANOĞLU E.

21st European Symposium on Quantitative Structure-Activity Relationship, Verona, Italy, 4 - 08 September 2016

Novel BRP 7 Derivatives Targeting FLAP Potent Inhibitors of Leukotriene Biosynthesis

GÜR Z. T., ÇALIŞKAN B., GERSTMEIER J., GARSCHA U., OLĞAÇ A., WERZ O., et al.

3rd EFMC Young Medicinal Chemist Symposium, Manchester, United Kingdom, 1 - 02 September 2016

Discovery of 4 5 Diarylisoxazol 3 Carboxylic Acid Skeleton as a Novel Chemotype for Inhibition of 5 Lipoxygenase Activating Proteın FLAP

ÇALIŞKAN B., ÇELİKOĞLU E., GERSTMEIER J., VOELKER S., GARSCHA U., OLĞAÇ A., et al.

EFMC International Symposium on Medicinal Chemistry 2016, Manchester, United Kingdom, 28 August - 01 September 2016

Exploratıon of the Chemıcal Space Around C 5 Posıtıon Of The Benzimidazole Nucleus in BRP 7 Towards More Potent Inhıbıtors of Human 5 Lıpoxygenase Actıvatıng Proteın FLAP

GÜR Z. T., ÇALIŞKAN B., GERSTMEIER J., OLĞAÇ A., NIKELS F., WERZ O., et al.

EFMC International Symposium on Medicinal Chemistry 2016, Manchester, United Kingdom, 28 August - 01 September 2016

Cloud Based Drug Discovery Platforms

OLĞAÇ A.

IBSS'2016 Resources and Techniques in Computational Drug Discovery, TANCA, Morocco, 23 - 26 May 2016

Hands on Evias Cloud Virtual Screening Module

OLĞAÇ A., BUDAK G., NUTI R.

IBSS'2016 Resources and Techniques in Computational Drug Discovery, TANCA, Morocco, 23 - 26 May 2016

Structure Guided Design of Novel Isoxazole and Benzimidazole Derivatives as Potent FLAP and 5 LO Inhibitors

OLĞAÇ A., CAROTTI A., BANOĞLU E., MACCHIARULO A.

IBSS'2016 Resources and Techniques in Computational Drug Discovery, Morocco, 23 - 26 May 2016

Evias Cloud Based Drug Discovery Platform

OLĞAÇ A., BUDAK G., OLĞAÇ S., NUTI R., CAROTTI A., BANOĞLU E.

High-Performance Modelling and Simulation for Big Data Applications - Management Committee & Working Group Meeting, Dublin, Ireland, 25 - 26 April 2016