Prof. Dr. AYSUN ÖZDEMİR

Makaleler 28

1. Development and optimization of Soluplus®/Pluronic-based polymeric micelles for bicalutamide delivery: characterization, lyophilization, stability, and cellular studies.

Ozaksun N. T., Tayyar T., Ozdemir A., Ark M., Incecayir T.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences , ss.107395, 2025 (SCI-Expanded, Scopus)

2. Targeting SASP with FDA-approved agents: minoxidil and diazoxide as potential senomorphic agents in cancer therapy

Şimay Demir Y. D., Ahmed I. M., Tayyar T., Özdemir A., Ark M.

TURKISH JOURNAL OF BIOCHEMISTRY , ss.1-12, 2025 (SCI-Expanded, Scopus, TRDizin) Sürdürülebilir Kalkınma

3. Fabrication and Characterization of Coenzyme Q10-Loaded Nanofibers for Potential Biomedical Applications.

Oğuz E., Tayyar T., Özdemir A., İnam O., Tort S.

Pharmaceutical development and technology , ss.1-20, 2025 (SCI-Expanded)

4. Caveolae and Rho Kinase: their implication of the senescent cell morphology and the secretion of the SASP in HeLa and A549 cancer cells.

Şimay Demir Y. D., Mohammed Ahmed I., Özdemir A., Ark M.

Medical oncology (Northwood, London, England) , cilt.42, sa.11, ss.475, 2025 (SCI-Expanded)

5. Evaluating the Effect of SASP Factors on the Proliferation of Cancer Cells using A Comparative Analysis of Three Distinct Methodologies

Şimay Demir Y. D., Tayyar T., Özdemir A., Ark M.

JOURNAL OF VISUALIZED EXPERIMENTS , cilt.223, sa.e68883, ss.1-19, 2025 (SCI-Expanded)

6. Evaluation of Antioxidant, Cytotoxic Effects and Phytochemical Profiles of Galls Caused by Eriophyidae mite in Juglans regia Leaves

BULUT S., Özüpek B., PEKACAR S., ÖZDEMİR A., Orhan D. D.

Fabad Journal of Pharmaceutical Sciences , cilt.49, sa.3, ss.525-538, 2024 (Scopus)

7. Temporal regulation of gene expression and pathways in chemotherapy-induced senescence in HeLa cervical cancer cell line

Sucularli C., Şimay Demir Y. D., Özdemir A., Ark M.

BIOSYSTEMS , cilt.237, 2024 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

8. Synthesis and molecular modeling of some novel hydroxypyrone derivatives as antidermatophytic agents

Karakaya G., Türe A., Özdemir A., Özçelik B., Aytemir M.

JOURNAL OF HETEROCYCLIC CHEMISTRY , cilt.1, sa.12, ss.1801-1812, 2022 (SCI-Expanded, Scopus)

9. Effect of Finishing-Polishing Procedures on Cytotoxicity of Resin-Based Restorative Materials via Real-Time Cell Analysis.

Çimen C., Demirsoy F. F., Özdemir A., Ark M., Özalp N.

The Journal of clinical pediatric dentistry , cilt.46, sa.1, ss.24-29, 2022 (SCI-Expanded)

10. The implication of ROCK 2 as a potential senotherapeutic target via the suppression of the harmful effects of the SASP: Do senescent cancer cells really engulf the other cells?

Demir Y. D., Özdemir A., Sucularli C., Benhür E., Ark M.

CELLULAR SIGNALLING , cilt.84, 2021 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

11. Antimigratory effect of pyrazole derivatives through the induction of STAT1 phosphorylation in A549 cancer cells

Şimay Demir Y. D., Özdemir A., Özdemir R. G., Cevher S. C., Çalışkan B., Ark M.

JOURNAL OF PHARMACY AND PHARMACOLOGY , cilt.73, sa.6, ss.808-815, 2021 (SCI-Expanded, Scopus)

12. A novel proteolytic cleavage of ROCK 1 in cell death: Not only by caspases 3 and 7 but also by caspase 2

Özdemir A., İbişoğlu B., Şimay Demir Y. D., Benhür E., Valipour F., Ark M.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS , cilt.547, ss.118-124, 2021 (SCI-Expanded, Scopus)

13. A novel ROCK inhibitor: off-target effects of metformin

ÖZDEMİR A., ARK M.

TURKISH JOURNAL OF BIOLOGY , cilt.45, sa.1, ss.35-45, 2021 (SCI-Expanded)

14. Synthesis of novel potential ROCK inhibitors and their antimigratory effects

Turanli S., Uslu A. G., Özdemir A.

ORGANIC COMMUNICATIONS , cilt.13, sa.4, ss.165-174, 2020 (ESCI) Sürdürülebilir Kalkınma

15. Evaluation of Cytotoxic Activity of New Benzimidazole-Piperazine Hybrids Against Human MCF-7 and A549 Cancer Cells

ÖZDEMİR A., Thranli S., ÇALIŞKAN B., Arka M., BANOĞLU E.

Pharmaceutical Chemistry Journal , cilt.53, sa.11, ss.1036-1046, 2020 (SCI-Expanded) Sürdürülebilir Kalkınma

16. The connection between the cardiac glycoside-induced senescent cell morphology and Rho/Rho kinase pathway

Simay Y. D., ÖZDEMİR A., Ibisoglu B., ARK M.

CYTOSKELETON , cilt.75, sa.11, ss.461-471, 2018 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

17. Gemcitabine hydrochloride-loaded liposomes and nanoparticles: comparison of encapsulation efficiency, drug release, particle size, and cytotoxicity

YALÇIN T. E., İLBASMIŞ TAMER S., Ibisoglu B., ÖZDEMİR A., ARK M., TAKKA S.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY , cilt.23, sa.1, ss.76-86, 2018 (SCI-Expanded)

18. Promising anticancer activity of Cyclotrichium niveum L. extracts through induction of both apoptosis and necrosis

ÖZDEMİR A., Yildiz M., ŞENOL DENİZ F. S., Simay Y. D., Iboglu B., GÖKBULUT A., et al.

FOOD AND CHEMICAL TOXICOLOGY , cilt.109, ss.898-909, 2017 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

19. Cardiac glycoside-induced cell death and Rho/Rho kinase pathway: Implication of different regulation in cancer cell lines

ÖZDEMİR A., Simay Y. D., Ibisoglu B., Yaren B., Bulbul D., ARK M.

STEROIDS , cilt.109, ss.29-43, 2016 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

20. Identification of the T-complex protein as a binding partner for newly synthesized cytoplasmic dynein intermediate chain 2

Oezdemir A., Machida K., Imataka H., Catling A. D.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS , cilt.469, sa.1, ss.126-131, 2016 (SCI-Expanded)

21. Chronic ouabain treatment induces Rho kinase activation

ÖZDEMİR A., Sahan G., Demirtas A., Aypar E., Gozubuyuk G., Turan N. N., et al.

ARCHIVES OF PHARMACAL RESEARCH , cilt.38, sa.10, ss.1897-1905, 2015 (SCI-Expanded)

22. Ouabain induces Rho-dependent rock activation and membrane blebbing in cultured endothelial cells

Ozdemir A., Ibisoglu B., Simay Y. D., Polat B., Ark M.

MOLECULAR BIOLOGY , cilt.49, sa.1, ss.138-143, 2015 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

23. xCELLigence Real Time Cell Analysis System A New Method for Cell Proliferation and Cytotoxicity

ÖZDEMİR A., ARK M.

Niche Journal , cilt.2, sa.2, ss.15-17, 2014 (Hakemli Dergi)

24. Epidermal Growth Factor Stimulates Extracellular-Signal Regulated Kinase Phosphorylation of a Novel Site on Cytoplasmic Dynein Intermediate Chain 2

Pullikuth A. K., Ozdemir A., Cardenas D., Bailey E., Sherman N. E., Pfister K. K., et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , cilt.14, sa.2, ss.3595-3620, 2013 (SCI-Expanded)

25. Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2

ARK M., ÖZDEMİR A., Polat B.

APOPTOSIS , cilt.15, sa.12, ss.1494-1506, 2010 (SCI-Expanded) Sürdürülebilir Kalkınma

26. Uvabain Aracılıklı Apoptotik Hücre Ölümleri ve Rho Kinaz Bir Proteomik Çalışma

BAYRAM E., ÖZDEMİR A., CİHAN A., ÖZEL DEMİRALP F. D., POLAT B., ARK M.

Mersin Üniversitesi Sağlık Bilimleri Dergisi , 2010 (Hakemli Dergi)

27. Rho Kinaz ve Apoptoz

ÖZDEMİR A., ARK M.

Mersin Üniversitesi Sağlık bilimleri Dergisi , 2009 (Hakemli Dergi)

28. Ouabain-induced hypertension and rho kinase

ÖZDEMİR A., Aypar E., Pahan G., Gozubuyuk G., Demirtap A., Turan N. N., et al.

FASEB JOURNAL , cilt.22, 2008 (SCI-Expanded)

Hakemli Bilimsel Toplantılarda Yayımlanmış Bildiriler 22

1. Elektroçekim Yöntemiyle Üretilen Koenzim Q10 Nanoliflerinin Nöroblastoma Hücre Hattında Sitotoksisitelerinin Belirlenmesi

Oğuz E., Tayyar T., Özdemir A., İnam O., Tort S.

7th International and 36th National Biophysics Congress, Bursa, Türkiye, 3 - 06 Eylül 2025, ss.67-68, (Özet Bildiri)

2. Targeting Therapy-Induced Senescence: Repurposing Approved Drugs to Suppress SASP in Cancer Cells

Özdemir A., Şimay Demir Y. D., Tayyar T., Mohammedahmed İ., Bozan E. B., Ark M.

2025 Cold Spring Harbor meeting: 89th Symposium: Senescence & Aging, New York, Amerika Birleşik Devletleri, 28 Mayıs - 01 Haziran 2025, ss.156, (Özet Bildiri)

3. Theophylline-induced HDAC activation as a novel senomorphic strategy—Suppression of SASP in senescent cancer cells

Ark M., Şimay Demir Y. D., Tayyar T., Turan T., Özdemir A.

2025 Cold Spring Harbor meeting: 89th Symposium: Senescence & Aging, New York, Amerika Birleşik Devletleri, 28 Mayıs - 01 Haziran 2025, ss.58, (Özet Bildiri)

4. Cardiotrophin 1: A Novel SASP Marker in Senescent MCF7 Cells

Özdemir A., Tayyar T., Şimay Demir Y. D., Ark M.

The 48th FEBS Congress, Milan, İtalya, 29 Haziran - 03 Temmuz 2024, ss.318, (Özet Bildiri)

5. KEMOTERAPİ İLE İNDÜKLENEN SENESENT HÜCRE SEKRETOMUNUN MODÜLASYONU İÇİN YENİ BİR HEDEF OLARAK LİPİT RAFTLARININ DEĞERLENDİRİLMESİ

Şimay Demir Y. D., Özdek E., Yeşilyurt Z. E., Özdemir A., Ark M.

2. ULUSLARARASI 27. ULUSAL FARMAKOLOJİ KONGRESİ, Antalya, Türkiye, 23 - 26 Kasım 2023, (Özet Bildiri)

6. Doksorubı̇sı̇n ile İndüklenen Senesent Hela Hücrelerı̇nde Parekoksı̇bı̇n Senomorfı̇k Etkı̇nlı̇ğı̇nı̇n Değerlendı̇rı̇lmesı̇

Bozan E. B., ÖZDEMİR A., ŞİMAY DEMİR Y. D., ARK M.

12th International Medicine and Health Sciences Researches Congress, Ankara, Türkiye, 18 - 19 Mart 2023, (Özet Bildiri)

7. A Novel Specific Cell Death Morphology for Cardiac Glycosides and MCF7 Cells: Implication of E-Cadherin and Cell-Cell Junctions

Özdemir A., Yeşilyurt Z. E., Şimay Demir Y. D., Ark M.

ICDS meeting "Future of Cell Death in Basic Science and Translational Medicine, İstanbul, Türkiye, 2 - 04 Temmuz 2022, (Özet Bildiri)

8. Teofilin A549 Hücrelerinde Senesens İle İlişkili Salgı Fenotipini (SASP) Modüle Etmektedir

Özdemir A., Kargıoğlu E., Yeşilyurt Z. E., Ark M.

10. ULUSAL MOLEKÜLER BİYOLOJİ VE BİYOTEKNOLOJİ KONGRESİ, Ankara, Türkiye, 18 - 20 Aralık 2021, ss.41, (Özet Bildiri)

9. A POTENTIAL SENOTHERAPEUTIC DRUG: THEOPHYLLINE RESTORES THE DOXORUBICIN-INDUCED SENESCENT CELL MORPHOLOGY IN A549 CELLS

Şahinoğlu E., Ark M., Özdemir A.

3rd International Gazi Pharma Symposium Series, Ankara, Türkiye, 8 - 10 Eylül 2021, (Yayınlanmadı) Sürdürülebilir Kalkınma

10. Antimigratory Effect of a Newly Sythesized Pyrazole Derivative Compound in A549 Cancer Cells

ÖZDEMİR A., Gönbe Özdemir R., ŞİMAY DEMİR Y. D., Cevher S. C., Şahinoğlu E., ÇALIŞKAN B., et al.

DGZ International Meeting, 17 - 19 Eylül 2018, cilt.44 Sürdürülebilir Kalkınma

11. Possible involvement of Rho kinase on the secretory activity of drug-induced senescent cells

simay y. d., ÖZDEMİR A., ARK M.

Cell Death CSHL 2017, 15 - 19 Ağustos 2017, (Özet Bildiri)

12. Holographic view of the senescent cells: Imagine all the senescent cells are not flattened

Simay Y. D., ÖZDEMİR A., Ibisoglu B., ARK M.

Experimental Biology Meeting, Illinois, Amerika Birleşik Devletleri, 22 - 26 Nisan 2017, cilt.31, (Özet Bildiri)

13. Anticancer activity of novel benzimidazole derivatives against MCF-7 cancer cells

ÖZDEMİR A., Uzunoglu S., ÇALIŞKAN B., BANOĞLU E., ARK M.

Experimental Biology Meeting, Illinois, Amerika Birleşik Devletleri, 22 - 26 Nisan 2017, cilt.31, (Özet Bildiri) Sürdürülebilir Kalkınma

14. A Possible Novel Mechanism in the Formation of Senescent Cell Morphology Caveolar Depletion

DİLBER ŞİMAY Y., ÖZDEMİR A., İBİŞOĞLU B., ARK M.

12th International Congress of Cell Biology, 21 - 25 Temmuz 2016

15. A novel Proteolytic Cleavage of ROCK 1 by caspase 2

İBİŞOĞLU B., ÖZDEMİR A., ŞİMAY Y. D., ARK M.

7th European Congress of Pharmacology, 26 - 30 Haziran 2016, (Özet Bildiri)

16. Cytotoxic Activity Appraisal of Different Extracts from Cyclotrichium Niveum L In Three Cell Lines

YILDIZ M., ŞENOL F. S., ÖZDEMİR A., İBİŞOĞLU B., ŞİMAY Y. D., ERDOĞAN ORHAN İ., et al.

the 18th International Congress Phtopharm 2014, 3 - 05 Temmuz 2014

17. Combination of ouabain and a specific ROCK inhibitor Y27632 in HeLa cells: implication of therapeutic benefits

Ibisoglu B., Simay Y., ÖZDEMİR A., ARK M.

Experimental Biology Meeting, California, Amerika Birleşik Devletleri, 26 - 30 Nisan 2014, cilt.28, (Özet Bildiri)

18. Cleavage of ROCK II: As a Common Phenomenon in Cell Death

ÖZDEMİR A., Ibisoglu B., Simay Y. D., Yaren B. M., ARK M.

Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB), Massachusetts, Amerika Birleşik Devletleri, 20 - 24 Nisan 2013, cilt.27, (Özet Bildiri)

19. Rock Inhibition Reduces Senescent Cell Size

Simay Y. D., Hosbas S., Ibisoglu B., Yildiz M., ÖZDEMİR A., ARK M.

Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB), Massachusetts, Amerika Birleşik Devletleri, 20 - 24 Nisan 2013, cilt.27, (Özet Bildiri)