Prof. Dr. BURCU ÇALIŞKAN

1. Enhanced Efficiency of the Microsomal Prostaglandin E₂ Synthase-1 Inhibitor AGU661 in Human Whole Blood by Encapsulation into PLGA-Based Nanoparticles

Dahlke P., Jordan P. M., Klepsch L. C., Ergül A. G., Stumpf S., Hoeppener S., et al.

MOLECULAR PHARMACEUTICS , 2025 (SCI-Expanded)

2. Harnessing structure-activity relationships to repurpose the FLAP inhibitor BRP-7 into potent and selective sEH inhibitors.

Çalışkan K., Karataş M., Jordan P. M., Çalışkan B., Werz O., Banoğlu E.

Bioorganic chemistry , cilt.165, ss.108997, 2025 (SCI-Expanded)

3. Potent soluble epoxide hydrolase inhibitors based on thiazole-5-carboxamide structure with imidazolidinone moiety as a secondary pharmacophore

LENGERLİ D., KOÇ B., Jordan P. M., ÇALIŞKAN K., ÇALIŞKAN B., Werz O., et al.

Bioorganic Chemistry , cilt.163, 2025 (SCI-Expanded)

4. Phenyl-benzyl-ureas with pyridazinone motif: Potent soluble epoxide hydrolase inhibitors with enhanced pharmacokinetics and efficacy in a paclitaxel-induced neuropathic pain model

LENGERLİ D., Bakht A., ÇALIŞKAN K., Dahlke P., BAL N. B., Jordan P. M., et al.

European Journal of Medicinal Chemistry , cilt.290, 2025 (SCI-Expanded)

5. Isoxazole-pyrimidine derivatives as TACC3 inhibitors: A novel modality to targeted cancer therapy

LENGERLİ D., Çalışkan Ö. A., ÇALIŞKAN K., Saatci Ö., Lim C., Vempati S., et al.

Bioorganic Chemistry , cilt.156, 2025 (SCI-Expanded)

6. 2-Phenylbenzothiazoles featuring heteroaryl sulfonamide end-capping substructures as developable mPGES-1 inhibitors

Yalcin T., Jordan P. M., OLĞAÇ A., Dahlke P., GÜR MAZ Z. T., BANOĞLU E., et al.

ARCHIV DER PHARMAZIE , cilt.358, sa.1, 2025 (SCI-Expanded, Scopus)

7. Novel Benzimidazole Derivatives as Potent Inhibitors of Microsomal Prostaglandin E₂ Synthase 1 for the Potential Treatment of Inflammation, Pain, and Fever

Ergul A. G., Jordan P. M., Dahlke P., BAL N. B., OLĞAÇ A., Uludag O., et al.

JOURNAL OF MEDICINAL CHEMISTRY , cilt.67, sa.23, ss.21143-21162, 2024 (SCI-Expanded, Scopus)

8. Novel 1,3,4-oxadiazole derivatives as highly potent microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors

Gür Maz T., Dahlke P., Ergül A. G., Olğaç A., Jordan P. M., Çalışkan B., et al.

BIOORGANIC CHEMISTRY , cilt.147, 2024 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

9. Targeting TACC3 Induces Immunogenic Cell Death and Enhances T-DM1 Response in HER2-Positive Breast Cancer

Gedik M. E., Saatci O., Oberholtzer N., ÜNER M., Akbulut Caliskan O., Cetin M., et al.

CANCER RESEARCH , cilt.84, sa.9, ss.1475-1490, 2024 (SCI-Expanded) Sürdürülebilir Kalkınma

10. Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification

Saatci O., Akbulut O., Cetin M., Sikirzhytski V., ÜNER M., LENGERLİ D., et al.

Cell Death and Differentiation , cilt.30, sa.5, ss.1305-1319, 2023 (SCI-Expanded)

11. Design, Synthesis and Evaluation of Aryl-Tailored Oxadiazole-thiones as New Urease Inhibitors

Gür Maz Z. T., Caliskan H. B., Capan İ., Caliskan B., Özçelik B., Banoglu E.

CHEMISTRYSELECT , cilt.8, sa.8, 2023 (SCI-Expanded, Scopus)

12. Benzoxazolone-5-Urea Derivatives as Human Soluble Epoxide Hydrolase (sEH) Inhibitors.

Gür Maz Z. T., Koç B., Jordan P. M., İbiş K., Çalışkan B., Werz O., et al.

ACS OMEGA , cilt.8, sa.2, ss.2445-2454, 2023 (SCI-Expanded, Scopus)

13. Vicinal Diaryl-Substituted Isoxazole and Pyrazole Derivatives with in Vitro Growth Inhibitory and in Vivo Antitumor Activity

Turanll S., NALBAT E., LENGERLİ D., İBİŞ K., Güntekin Ergün S., Akhan Güzelcan E., et al.

ACS Omega , cilt.7, sa.41, ss.36206-36226, 2022 (SCI-Expanded) Sürdürülebilir Kalkınma

14. Quinazoline-4(3H)-one-7-carboxamide Derivatives as Human Soluble Epoxide Hydrolase Inhibitors with Developable 5-Lipoxygenase Activating Protein Inhibition

Turanli S., Ergul A. G., Jordan P. M., Olğaç A., Çalışkan B., Werz O., et al.

ACS OMEGA , cilt.7, sa.41, ss.36354-36365, 2022 (SCI-Expanded, Scopus)

15. Development and molecular modeling studies of new thiadiazole piperazine urea derivatives as potential fatty acid amide hydrolase inhibitors

Gür Maz Z. T., Turanlı S., Çalışkan H. B., Çalışkan B., Banoğlu E.

ARCHIV DER PHARMAZIE , cilt.355, sa.8, ss.1-11, 2022 (SCI-Expanded)

16. Discovery and Optimization of Piperazine Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors.

Çapan İ., Jordan P. M., Olğaç A., Çalışkan B., Kretzer C., Werz O., et al.

ChemMedChem , cilt.17, sa.12, 2022 (SCI-Expanded, Scopus)

17. Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase

Ergül A. G., Maz T. G., Kretzer C., Olğaç A., Jordan P. M., Çalışkan B., et al.

European Journal of Medicinal Chemistry , cilt.231, 2022 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

18. Synthesis and biological evaluation of novel isoxazole-piperazine hybrids as potential anti-cancer agents with inhibitory effect on liver cancer stem cells

Ibis K., NALBAT E., ÇALIŞKAN B., KAHRAMAN D. C., Cetin-Atalay R., BANOĞLU E.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , cilt.221, 2021 (SCI-Expanded) Sürdürülebilir Kalkınma

19. Simple heteroaryl modifications in the 4,5-diarylisoxazol-3-carboxylic acid scaffold favorably modulates the activity as dual mPGES-1/5-LO inhibitors with in vivo efficacy

Gurses T., OLĞAÇ A., Garscha U., GÜR MAZ Z. T., BAL N. B., Uludag O., et al.

BIOORGANIC CHEMISTRY , cilt.112, 2021 (SCI-Expanded, Scopus)

20. Exploration of anti-tyrosinase effect of Geranium glaberrimum Boiss. & Heldr. with in silico approach and survey of 21 Geranium species

Celikler Ozer O., Erdoğan Orhan İ., Çalışkan B., Senol Deniz F. S., Gokbulut A., Gur Maz T., et al.

JOURNAL OF HERBAL MEDICINE , cilt.27, 2021 (SCI-Expanded, Scopus)

21. Antimigratory effect of pyrazole derivatives through the induction of STAT1 phosphorylation in A549 cancer cells

Şimay Demir Y. D., Özdemir A., Özdemir R. G., Cevher S. C., Çalışkan B., Ark M.

JOURNAL OF PHARMACY AND PHARMACOLOGY , cilt.73, sa.6, ss.808-815, 2021 (SCI-Expanded, Scopus)

22. Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives

Gür Maz Z. T., Karaca N., Levent S., Çalışkan B., Demirci F., Banoğlu E.

JOURNAL OF RESEARCH IN PHARMACY , cilt.25, sa.5, ss.531-539, 2021 (ESCI)

23. A Highly Potent TACC3 Inhibitor as a Novel Anticancer Drug Candidate

Akbulut O., Lengerli D., Saatci O., Duman E., ŞEKER U. Ö. Ş., Isik A., et al.

MOLECULAR CANCER THERAPEUTICS , cilt.19, sa.6, ss.1243-1254, 2020 (SCI-Expanded) Sürdürülebilir Kalkınma

24. Evaluation of Cytotoxic Activity of New Benzimidazole-Piperazine Hybrids Against Human MCF-7 and A549 Cancer Cells

ÖZDEMİR A., Thranli S., ÇALIŞKAN B., Arka M., BANOĞLU E.

Pharmaceutical Chemistry Journal , cilt.53, sa.11, ss.1036-1046, 2020 (SCI-Expanded) Sürdürülebilir Kalkınma

25. Benzimidazole derivatives as potent and isoform selective tumor-associated carbonic anhydrase IX/XII inhibitors

Uslu A. G., Maz T. G., Nocentini A., BANOĞLU E., Supuran C. T., ÇALIŞKAN B.

BIOORGANIC CHEMISTRY , cilt.95, 2020 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

26. Novel Piperazine Amides of Cinnamic Acid Derivatives as Tyrosinase Inhibitors

GÜR MAZ Z. T., ŞENOL DENİZ F. S., Shekfeh S., ERDOĞAN ORHAN İ., BANOĞLU E., ÇALIŞKAN B.

LETTERS IN DRUG DESIGN & DISCOVERY , cilt.16, sa.1, ss.36-44, 2019 (SCI-Expanded, Scopus)

27. A Multi-step Virtual Screening Protocol for the Identification of Novel Non-acidic Microsomal Prostaglandin E-2 Synthase-1 (mPGES-1) Inhibitors

Shekfeh S., ÇALIŞKAN B., Fischer K., Yalcin T., Garscha U., Werz O., et al.

CHEMMEDCHEM , cilt.14, sa.2, ss.273-281, 2019 (SCI-Expanded) Sürdürülebilir Kalkınma

28. Synthesis and cellular bioactivities of novel isoxazole derivatives incorporating an arylpiperazine moiety as anticancer agents

ÇALIŞKAN B., NALBAT E., Ibis K., Guzelcan E. A., ATALAY R., BANOĞLU E.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY , cilt.33, sa.1, ss.1352-1361, 2018 (SCI-Expanded) Sürdürülebilir Kalkınma

29. Drug discovery approaches targeting 5-lipoxygenase-activating protein (FLAP) for inhibition of cellular leukotriene biosynthesis

Gür Maz Z. T., Çalışkan B., Banoğlu E.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , cilt.153, ss.34-48, 2018 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

30. Identification of multi-target inhibitors of leukotriene and prostaglandin E-2 biosynthesis by structural tuning of the FLAP inhibitor BRP-7

GÜR MAZ Z. T., ÇALIŞKAN B., Garscha U., OLĞAÇ A., Schubert U. S., Gerstmeier J., et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , cilt.150, ss.876-899, 2018 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

31. BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly

Garscha U., Voelker S., Pace S., Gerstmeier J., Emini B., Liening S., et al.

BIOCHEMICAL PHARMACOLOGY , cilt.119, ss.17-26, 2016 (SCI-Expanded)

32. Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7

Levent S., Gerstmeier J., Olğaç A., Nikels F., Garscha U., Carotti A., et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , cilt.122, ss.510-519, 2016 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

33. 4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP)

Banoğlu E., Celikoglu E., Voelker S., Olğaç A., Gerstmeier J., Garscha U., et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , cilt.113, ss.1-10, 2016 (SCI-Expanded, Scopus)

34. Synthesis and preliminary mechanistic evaluation of 5-(p-tolyl)-1-(quinolin-2-yl)pyrazole-3-carboxylic acid amides with potent antiproliferative activity on human cancer cell lines

Pirol S. C., ÇALIŞKAN B., Durmaz I., ATALAY R., BANOĞLU E.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , cilt.87, ss.140-149, 2014 (SCI-Expanded)

35. The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP)

Pergola C., Gerstmeier J., Moench B., Caliskan B., Luderer S., Weinigel C., et al.

British Journal of Pharmacology , cilt.171, sa.12, ss.3051-3064, 2014 (SCI-Expanded)

36. Chromatographic separation and biological evaluation of benzimidazole derivative enantiomers as inhibitors of leukotriene biosynthesis

Sardella R., Levent S., Ianni F., ÇALIŞKAN B., Gerstmeier J., Pergola C., et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS , cilt.89, ss.88-92, 2014 (SCI-Expanded)

37. Pyrazole derivatives as inhibitors of arachidonic acid-induced platelet aggregation

Levent S., ÇALIŞKAN B., Ciftci M., ÖZKAN Y., Yenicesu I., ÜNVER H., et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , cilt.64, ss.42-53, 2013 (SCI-Expanded) Sürdürülebilir Kalkınma

38. Synthesis and evaluation of analgesic, anti-inflammatory, and anticancer activities of new pyrazole-3(5)-carboxylic acid derivatives

ÇALIŞKAN B., Yilmaz A., Evren I., Menevse S., Uludag O., BANOĞLU E.

MEDICINAL CHEMISTRY RESEARCH , cilt.22, sa.2, ss.782-793, 2013 (SCI-Expanded) Sürdürülebilir Kalkınma

39. Overview of recent drug discovery approaches for new generation leukotriene A(4) hydrolase inhibitors

ÇALIŞKAN B., BANOĞLU E.

EXPERT OPINION ON DRUG DISCOVERY , cilt.8, sa.1, ss.49-63, 2013 (SCI-Expanded)

40. Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP)

BANOĞLU E., ÇALIŞKAN B., Luderer S., EREN G., Ozkan Y., Altenhofen W., et al.

BIOORGANIC & MEDICINAL CHEMISTRY , cilt.20, sa.12, ss.3728-3741, 2012 (SCI-Expanded) Sürdürülebilir Kalkınma

41. Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils

ÇALIŞKAN B., Luderer S., Ozkan Y., Werz O., BANOĞLU E.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , cilt.46, sa.10, ss.5021-5033, 2011 (SCI-Expanded) Sürdürülebilir Kalkınma

42. Synthesis, antioxidant and antimicrobial evaluation of simple aromatic esters of ferulic acid

Ergun B., ÇOBAN T., Onurdag F. K., BANOĞLU E.

Archives of Pharmacal Research , cilt.34, sa.8, ss.1251-1261, 2011 (SCI-Expanded)

43. Stable ester and amide conjugates of some NSAIDs as analgesic and antiinflammatory compounds with improved biological activity

ULUDAĞ M. O., Ergun B., Alkan D. A., Ercan N., Ozkan G. Y., BANOĞLU E.

Turkish Journal of Chemistry , cilt.35, sa.3, ss.427-439, 2011 (SCI-Expanded)

44. Synthesis of 1,5-diarylpyrazol-3-propanoic acids towards inhibition of cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4 formation

Ergun B., Teresa Nunez M., Labeaga L., Ledo F., Darlington J., Bain G., et al.

Arzneimittel-Forschung/Drug Research , cilt.60, sa.8, ss.497-505, 2010 (SCI-Expanded)

45. Synthesis and chromatographic resolution of conformationally constrained analogues of homotaurine

Fulco M. C., Marinozzi M., Ergun B., Sardella R., Natalini B., Pellicciari R.

TETRAHEDRON , cilt.65, sa.42, ss.8756-8762, 2009 (SCI-Expanded)

46. Screening and evaluation of antioxidant activity of some pyridazine derivatives

Caliskan-Erguen B., Suekueroglu M. K., ÇOBAN T., BANOĞLU E., SÜZEN S.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY , cilt.23, sa.2, ss.225-229, 2008 (SCI-Expanded)

47. Synthesis of the amide derivatives of 3-[1-(3-pyridazinyl)-5-phenyl-1H-pyrazole-3-yl]propanoic acids as potential analgesic compounds

BANOĞLU E., Sukuroglu M. K., Ergun B., BAYTAŞ S., Aypar E., Aark M.

TURKISH JOURNAL OF CHEMISTRY , cilt.31, sa.6, ss.677-687, 2007 (SCI-Expanded)

48. Screening and evaluation of rat kidney aldose reductase inhibitory activity of some pyridazine derivatives

Sukuroglu M. K., Caliskan-Ergun B., Das-Evcimen N., Sarikaya M., Banoğlu E., Suzen S.

MEDICINAL CHEMISTRY RESEARCH , cilt.15, ss.443-451, 2007 (SCI-Expanded) Sürdürülebilir Kalkınma

49. Synthesis, analgesic, and anti-inflammatory activities of [6-(3,5-dimethyl-4-chloropyrazole-1-yl)-3(2H-pyridazinon-2-yl]acetamides

Sukuroglu M. K., Ergun B., Unlu S., Sahin M., Kupeli E., Yesilada E., et al.

ARCHIVES OF PHARMACAL RESEARCH , cilt.28, sa.5, ss.509-517, 2005 (SCI-Expanded)

50. Synthesis of amide derivatives of [6-(3,5-dimethylpyrazol-1-yl)-3(2H)- pyridazinone-2-yl]acetic acid and their analgesic and anti-inflammatory properties

BANOĞLU E., Akoglu C., Unlu S., Ergun B., Kupeli E., Yesilada E., et al.

Arzneimittel-Forschung/Drug Research , cilt.55, sa.9, ss.520-527, 2005 (SCI-Expanded)

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